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Cell cycle and Checkpoints in Oncology: New Therapeutic
Targets
Pommier Y, Kohn KW
Med Sci (Paris). 2003 Feb;19(2):173-86
[Article in French]
Abstract:
Leland H. Hartwell, Paul M. Nurse et R. Timothy Hunt just received the Nobel price for
their discovery of the molecular components of the cell cycle and cell cycle checkpoints.
This review is an update of the molecular networks driving the cell cycle and its regulation,
and of the importance of this knowledge for understanding the mechanisms driving oncogenesis
and therapeutic developments.
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