| Link | Description |
|---|---|
| Manuscript and Enlarged Figures | |
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Text of manuscript with figures (PDF file) |
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Figure 1. The NCI Cancer Drug Discover - Development Pipeline (PDF) Legend |
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Figure 2. Cluster trees of cells on the basis of genes (A) and drugs (B) (PDF) Legend |
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Figure 3. Cluster trees of drugs on the basis of cells (A) and genes (B) (PDF) Legend |
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Figure 4. Color-coded clustered image map (CIM) relating 118
"mechanism of action" drugs to 1375 genes (PDF) Legend |
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Figure 5. Scatter plot of L-Asparaginase (drug) and Asparagine Synthetase
(gene) (PDF) Legend |
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Table 1. Database for drugs analyzed in this study in Excel format |
| Databases
* If you downloaded *.sit or *.sit.bin file, double click the file icon to generate text file. |
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Drug activity data (A-matrix), tab delimited (1400 drugs x 60
cells) (687 Kb) Description Click on icon to view *** UPDATED 12/19/01 *** (Download compressed: PC/UNIX Mac) (previous version) |
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Drug activity data of 118 "Mechanism of Action" drugs,
tab delimited (118 drugs x 60 cells ) (33 Kb) Description Click on icon to view *** UPDATED 12/19/01 *** (Download compressed: PC/UNIX Mac) (previous version) |
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Gene expression data (T-matrix), tab delimited (1375 genes x 60
cells) (579 Kb) Description Click on icon to view *** UPDATED 12/19/01 *** (Download compressed: PC/UNIX) (previous version) |
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Target matrix (15 Kb) Description Click on icon to view *** UPDATED 01/09/02 *** (Download compressed: PC/UNIX) |
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Gene expression data (all genes, 9,706), tab delimited
(9,706 genes x 60 cells ) (6.4 MB) Description Click on icon to view *** UPDATED 12/19/01 *** (Download compressed: PC/UNIX Mac) (previous version) |
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Gene-drug correlation data (AT-matrix), tab delimited (1375 genes x
118 drugs) (1.1 Mb) Description Click on icon to view (Download compressed: PC/UNIX Mac) |
| Tools For Data
Analysis And Visualization |
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Generate a color-coded "Clustered Image Map" to explore patterns of gene-gene, drug-drug, or gene-drug relationship in the NCI60 data sets. |
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For your favorite drug or gene: search for high positive and negative gene-gene, drug-drug, or gene-drug correlations. |
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Display correlation statistics and scattergram for a drug/gene/cell pair (i.e., a drug-drug, gene-gene, cell-cell, drug-cell, or gene-cell pair) |
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Upload your own data set and generate a Color-Coded Clustered Image Map (CIM) for single matrix |
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Upload your own data sets and generate a Color-Coded Clusterd Image Map (CIM) for multiple matrix (Under construction) |
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Upload your own data set and generate a Color-Coded Image Map (CIM) for no cluster |
| Links | |
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Nature Genetics |
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Stanford Genomic Resources |
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The NCI Developmental Therapeutics Program |
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Gene Chips microarray review site |
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DCS/CIT microarray databases and tools |