Drug activity z scores

This tool compiles drug activity levels from all NCI60 experiments the pass quality control.

The tool provides an Excel spreadsheet for each compound the user has input that includes:

  1. average compound activity Z scores in a tabular form and visualized as a bar graph (see below).
  2. all activity values for those experiments that passed quality control to a maximum of 253
  3. the z-score transforms for each experiment that passed quality control to a maximum of 253.

The data, absent quality control and z score transforms, is queryable using Query Drug Data (http://discover.nci.nih.gov/cellminer/drugQuery.do).
The data may be obtained in toto at Download Data Sets under "Compounds: DTP NCI60" (http://discover.nci.nih.gov/cellminer/loadDownload.do).
A brief platform description is available in Data Set Metadata under "Drug: DTP_NCI60" (http://discover.nci.nih.gov/cellminer/datasets.do).
Drug activity levels expressed as 50% growth-inhibitory levels (GI50) are determined by the Developmental Theraputics Program (DTP) (http://dtp.nci.nih.gov/) at 48 hours using the sulforhodamine B assay (Rubenstein, J Natl Cancer Inst, 1990).


Table 1: Average compound activity Z scores

Cell lines Average Z scores

BR:MCF7 -1.44
BR:MDA_MB_231 -0.52
BR:HS578T 0.36
BR:BT_549 0.66
BR:T47D -0.28
CNS:SF_268 0.71
CNS:SF_295 -0.28
CNS:SF_539 0.75
CNS:SNB_19 -1.46
CNS:SNB_75 0.04
CNS:U251 -0.15
CO:COLO205 -1.1
CO:HCC_2998 -1.09
CO:HCT_116 0.3
CO:HCT_15 -1.4
CO:HT29 -1.67
CO:KM12 -1.6
CO:SW_620 0.82
LE:CCRF_CEM 0.95
LE:HL_60 0.83
LE:K_562 0.89
LE:MOLT_4 0.9
LE:RPMI_8226 0.97
LE:SR -0.13
ME:LOXIMVI 1.01
ME:MALME_3M 0.77
ME:M14 0.86
ME:SK_MEL_2 1.56
ME:SK_MEL_28 0.41
ME:SK_MEL_5 0.39
ME:UACC_257 0.41
ME:UACC_62 0.75
ME:MDA_MB_435 0.94
ME:MDA_N 0.87
LC:A549 -1.55
LC:EKVX -0.84
LC:HOP_62 0.83
LC:HOP_92 0.38
LC:NCI_H226 0.37
LC:NCI_H23 -1.42
LC:NCI_H322M -1.32
LC:NCI_H460 -1.01
LC:NCI_H522 -1.11
OV:IGROV1 -1.92
OV:OVCAR_3 -1.2
OV:OVCAR_4 -1
OV:OVCAR_5 -1.34
OV:OVCAR_8 0.55
OV:SK_OV_3 0.2
OV:NCI_ADR_RES 0
PR:PC_3 0.38
PR:DU_145 0.49
RE:786_0 0.87
RE:A498 -0.99
RE:ACHN -1.19
RE:CAKI_1 0.84
RE:RXF_393 1.26
RE:SN12C 0.81
RE:TK_10 0.68
RE:UO_31 0.77

 
 
      This is a bar chart of the nci60 cell lines with the Drug activity z-score values (a visual representation of the data contained in table 1).