Protein RPPA mean values

This tool provides access to the average log2 intensity values for protein lysates analyzed using 162 antibodies for 94 genes.

The tool provides an Excel spreadsheet for each gene the user has input that includes:

  1. mean centered protein levels in tabular form and as a bar plot (see below)
  2. a table of protein levels.
  3. distribution of protein levels by bin in tabular form and as a bar plot

The antibodies are as described in AbMiner (http://discover.nci.nih.gov/abminer/).
The data is queryable by gene or chromosomal location using Query Genomic Data under "Protein: Lysate Array" (http://discover.nci.nih.gov/cellminer/queryLoad.do).
The data may be obtained in toto at Download Data Sets under "Protein: Lysate Array" (http://discover.nci.nih.gov/cellminer/loadDownload.do).
A brief platform description is available in Data Set Metadata under "Protein: Lysate Array" (http://discover.nci.nih.gov/cellminer/datasets.do).
The protein levels are measured as described in Nishizuka et al, Proc Natl Acad Sci USA, 2003.


Table 1: Mean centered protein levels

Cell lines Protein level

BR:MCF7 0.114
BR:MDA_MB_231 -0.763
BR:HS578T -0.263
BR:BT_549 0.073
BR:T47D 0.151
CNS:SF_268 -0.282
CNS:SF_295 -1.216
CNS:SF_539 -1.208
CNS:SNB_19 -0.683
CNS:SNB_75 0.204
CNS:U251 -1.071
CO:COLO205 -0.522
CO:HCC_2998 0.415
CO:HCT_116 -0.162
CO:HCT_15 -0.643
CO:HT29 -1.675
CO:KM12 -0.565
CO:SW_620 0.098
LE:CCRF_CEM 0.028
LE:HL_60 0.385
LE:K_562 0.039
LE:MOLT_4 -1.073
LE:RPMI_8226 1.141
LE:SR 0.46
ME:LOXIMVI -0.212
ME:MALME_3M 0.082
ME:M14 0.129
ME:SK_MEL_2 0.62
ME:SK_MEL_28 1.57
ME:SK_MEL_5 0.24
ME:UACC_257 1.656
ME:UACC_62 0.327
ME:MDA_MB_435 0.1163
ME:MDA_N 0.013
LC:A549 -1.77
LC:EKVX -0.041
LC:HOP_62 -0.981
LC:HOP_92 0.211
LC:NCI_H226 -0.988
LC:NCI_H23 -0.108
LC:NCI_H322M 0.583
LC:NCI_H460 -0.33
LC:NCI_H522 0.174
OV:IGROV1 0.241
OV:OVCAR_3 0.494
OV:OVCAR_4 0.166
OV:OVCAR_5 1.174
OV:OVCAR_8 0.953
OV:SK_OV_3 -0.342
OV:NCI_ADR_RES -1.469
PR:PC_3 1.14
PR:DU_145 1.449
RE:786_0 0.652
RE:A498 0.461
RE:ACHN 0.38
RE:CAKI_1 1.279
RE:RXF_393 0.307
RE:SN12C -0.869
RE:TK_10 -0.006
RE:UO_31 -0.335

      This is a bar chart of the nci60 cell lines with the mean centered protein levels (a visual representation of the data contained in table 1).