Release Notes
Version 2025.3 - 09/21/2025
- Gene version: Hg19 from NCBI
- DTP drug date: 07/07/2025
- Database version: v2.15
- FDA NSCs passed QC: 326
- Clinical trial NSCs passed QC: 563
- Applied quality control to HTS384 drug z-score data
- HTS384 compounds passed QC: 863
- Gene version: Hg19 from NCBI
- DTP drug date: 03/01/2025
- Database version: v2.14.1
- FDA NSCs passed QC: 326
- Clinical trial NSCs passed QC: 563
- Updated FDA approved drug list
- Added HTS384 NCI-60 drug data
- The DTP NCI-60 drug data was downloaded from DTP NCI-60 Growth Inhibition Data
- The HTS384 NCI-60 drug data was download from HTS384 NCI60: The Next Phase of the NCI60 Screen
- Gene version: Hg19 from NCBI
- DTP drug pull date: 06/29/2024
- Database version: v2.13
- FDA NSCs passed QC: 318
- Clinical trial NSCs passed QC: 563
- Gene version: Hg19 from NCBI
- DTP drug pull date: 03/01/2024
- Database version: v2.12
- FDA NSCs passed QC: 318
- Clinical trial NSCs passed QC: 563
- Added NCI-60 Cell Surface Protein data
- Gene version: Hg19 from NCBI
- DTP drug pull date: 09/01/2023
- Database version: v2.11
- FDA NSCs passed QC: 316
- Clinical trial NSCs passed QC: 551
- Gene version: Hg19 from NCBI
- DTP drug pull date: 03/02/2023
- Database version: v2.10
- Implemented new download data set page
- Gene version: Hg19 from NCBI
- DTP drug pull date: 09/01/2022
- Database version: v2.9
- Implemented US Web Design System UI/UX
- Updated drug status list
- Added Histone Protein H3K27ac and H3K4me3
- Gene version: Hg19 from NCBI
- DTP drug pull date: 03/01/2022
- Database version: v2.8.1
- Refactored code for drug z-score database batch scripts.
- Gene version: Hg19 from NCBI
- DTP drug pull date: 08/01/2021
- Database version: v2.7
- Updated to limit the Pattern Comparison Analysis request job to one at a time.
- Gene version: Hg19 from NCBI
- DTP drug pull date: 04/01/2021
- Database version: v2.6
- Added user input validation in the query drug almanac data
- Added a new page to display drug status list for FDA approved and Clinical trial drugs
- Gene version: Hg19 from NCBI
- DTP drug pull date: 12/01/2020
- Database version: v2.5
- Added drug almanac combo scores in the cell line signature analysis
- Added querying drug almanac data with NSC pairs or compound name pairs
- Added download drug almanac data in the download data set page
- Updated phenotypic parameters in Pattern Comparison
- Gene version: Hg19 from NCBI
- DTP drug pull date: 10/23/2019
- Database version: v2.4.2
- Changed cell line signature and cross-correlation analysis entry limit to 10
- Added release notes in home page and created a historical release notes page
- Added NCI-60 Almanac combo score data in the database
- Gene version: Hg19 from NCBI
- DTP drug pull date: 2017
- Database version: v2.2
- Newly added dataset: RNA:RNA-seq, Protein: SWATH
- Newly updated analysis:
- RNA-seq in cell line signature, pattern comparison and drug vs gene variant/isoforms
- Protein SWATH in cell line signature, cross-correlations and pattern comparison
- Gene version: Hg19 from NCBI
- DTP drug pull date: 2017
- Database version: v2.2
- Renamed Protein: Lysate Array to Protein: Antibody Array DTB
- Renamed Protein: Antibody Array to Protein: Antibody Array MDA
- Updated Protein: Antibody Array MDA in Data Set Metadata page
| CellMiner Data Synopsis | |||||
|---|---|---|---|---|---|
| Database Version | 2.11 | 2.12 | 2.13 | 2.14.1 | 2.15 |
| Starting Date | 09/2023 | 03/2024 | 06/2024 | 04/2025 | 09/2025 |
| Drugs | |||||
| Total compounds | 57,455 | 57,673 | 57,882 | 58,329 | 58,953 |
| Compounds (passed QC) | 24,980 | 25,147 | 25,293 | 25,374 | 25,731 |
| Known MOA | 1,460 | 1,460 | 1,460 | 1,460 | 1,460 |
| FDA NSCs | 438 | 438 | 438 | 472 | 472 |
| FDA NSCs passed QC | 316 | 318 | 318 | 326 | 326 |
| FDA drugs | 325 | 325 | 325 | 359 | 359 |
| FDA drugs passed QC | 233 | 234 | 234 | 242 | 242 |
| Clinical trial NSCs | 739 | 739 | 739 | 739 | 739 |
| Clinical trial NSCs passed QC | 551 | 563 | 563 | 563 | 563 |
| Clinical trial drugs | 691 | 691 | 691 | 691 | 691 |
| Clinical trial drugs passed QC | 520 | 530 | 530 | 530 | 530 |
| Total HTS384 compounds | 0 | 0 | 0 | 1,000 | 1,000 |
| HTS384 compounds passed QC | 0 | 0 | 0 | 0 | 863 |
| DNA | |||||
| aCGH (DNA copy number) | 23,222 | 23,222 | 23,222 | 23,222 | 23,222 |
| AA changing gen. var. | 12,945 | 12,945 | 12,945 | 12,945 | 12,945 |
| Function affecting gen. var. | 9,307 | 9,307 | 9,307 | 9,307 | 9,307 |
| DNA methylation | 17,552 | 17,552 | 17,552 | 17,552 | 17,552 |
| RNA | |||||
| microRNAs | 360 | 360 | 360 | 360 | 360 |
| Microarray Transcript z scores total | 26,186 | 26,186 | 26,186 | 26,186 | 26,186 |
| RNA-seq gene transcripts | 23,808 | 23,808 | 23,808 | 23,808 | 23,808 |
| Protein | |||||
| Proteins, RPLA (162 antibodies) | 94 | 94 | 94 | 94 | 94 |
| Proteins, mass spectrometry | 3,162 | 3,162 | 3,162 | 3,162 | 3,162 |
| Phenotype | |||||
| Phenotypic parameters | 73 | 73 | 73 | 73 | 73 |
| Totals | |||||
| Molecular totals | 107,329 | 107,329 | 107,329 | 107,329 | 107,329 |
| Compound activity totals | 24,980 | 25,147 | 25,293 | 25,374 | 25,731 |
- The DTP NCI-60 Growth Inhibition Data loaded onto Cellminer.
- The compounds that passed Cellminer quality control as described in (PMID 22802077).
- The number of compounds have known drug mechanism of action (MOA).
- The number of National Service Center (NSC) identifiers for Food and Drug Administration (FDA) approved drugs. There may be more than one per drug.
- The number of National Service Center (NSC) identifiers for Food and Drug Administration (FDA) approved drugs that passed CellMiner QC. There may be more than one per drug.
- The number of drugs approved by the Food and Drug Administration (FDA).
- The number of drugs approved by the Food and Drug Administration (FDA) and passed CellMiner QC.
- The number of National Service Center (NSC) identifiers for clinical trial drugs. There may be more than one per drug.
- The number of National Service Center (NSC) identifiers for clinical trial drugs that passed CellMiner QC. There may be more than one per drug.
- The number of drugs in, or have been in, some level of clinical trial.
- The number of drugs in, or have been in, some level of clinical trial and passed CellMiner QC.
- The DTP HTS384 NCI-60 compounds loaded onto Cellminer.
- The DTP HTS384 NCI-60 compounds passed CellMiner QC.
- The number of unique genes with DNA copy number from array comparative hybridization (aCGH) (PMID 24670534).
- The number of unique genes with DNA exome sequence amino acid (AA) changing genetic variants (PMID 26048278).
- The number of unique genes with DNA exome sequence protein function affecting genetic variants (PMID 26048278).
- The number of unique genes with DNA methylation levels (PMID 27923837).
- The number of unique microRNAs with transcript expression levels (PMID 20442302).
- The number of unique genes with transcript expression levels from microarray analysis (PMID 22802077).
- The number of unique genes with transcript expression levels from RNA sequencing (RNAseq) (PMID 31113817).
- The number of unique genes with protein expression as measured by reverse phase lysate arrays (RPLA) (PMID 14623978).
- The number of unique genes with protein expression as measured by mass spectrometry (PMID 31733513).
- The number of phenotypic parameters Pattern Comparison (PMID 26048278).
- The summation of aCGH DNA copy number, AA Changing gen. var., DNA methylation, microRNAs, Microarray Transcript z scores total, RNA-seq, Protein RPLA and Protein mass spectrometry.
- Compound activity totals are from Compounds and Natural products (passed QC).
