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CellMiner Address: https://discover.nci.nih.gov/cellminer/
CellMiner Database Version: 2.5
Human Genome Version: HG-19
Date: 01-26-2021
Table 3: Drug mechanism of action abbreviation definitions
CategoryCategory descriptionAbbreviationsDefinitions of drug mechanism of action abbreviations
NonCanNon-cancer drug with FDA approvalAntAntibiotic
NonCanNon-cancer drug with FDA approvalAnti-bone resorpanti-Bone resorption
NonCanNon-cancer drug with FDA approvalAntihemorrhagicStops bleeding
NonCanNon-cancer drug with FDA approvalCardGCardiac Glycoside
NonCanNon-cancer drug with FDA approvalCardioprotectiveHelps prevent heart problems caused by doxorubicin.
NonCanNon-cancer drug with FDA approvalCathCathartic
NonCanNon-cancer drug with FDA approvalMalMalaria
NonCanNon-cancer drug with FDA approvalPsyAntipsychotic
NonCanNon-cancer drug with FDA approvalSteSteroid
PKProtein kinase inhibitorAKTAkt inhibitor
PKProtein kinase inhibitorAKT1AKT1 inhibitor
PKProtein kinase inhibitorAKT2AKT2 inhibitor
PKProtein kinase inhibitorAKT3AKT3 inhibitor
PKProtein kinase inhibitorALKALK inhibitor
PKProtein kinase inhibitorATMATM inhibitor
PKProtein kinase inhibitorATRATR inhibitor
PKProtein kinase inhibitorAURKAurora kinase inhibitor
PKProtein kinase inhibitorAXLAxl inhibitor
PKProtein kinase inhibitorBLKBLK inhibitor
PKProtein kinase inhibitorBRAFBRAF inhibitor
PKProtein kinase inhibitorBTKBTK inhibitor
PKProtein kinase inhibitorBUB1BUB1 inhibitor
PKProtein kinase inhibitorCDC7CDC7 inhibitor
PKProtein kinase inhibitorCDKCDK inhibitor
PKProtein kinase inhibitorCDK1CDK1 inhibitor
PKProtein kinase inhibitorCDK19CDK19 inhibitor
PKProtein kinase inhibitorCDK2CDK2 inhibitor
PKProtein kinase inhibitorCDK4CDK4 inhibitor
PKProtein kinase inhibitorCDK5CDK5 inhibitor
PKProtein kinase inhibitorCDK6CDK6 inhibitor
PKProtein kinase inhibitorCDK7CDK7 inhibitor
PKProtein kinase inhibitorCDK8CDK8 inhibitor
PKProtein kinase inhibitorCDK9CDK9 inhibitor
PKProtein kinase inhibitorCHEKCHK inhibitor (CHEK1, CHEK2)
PKProtein kinase inhibitorCHEK1CHEK1 inhibitor
PKProtein kinase inhibitorCHEK2CHEK2 inhibitor
PKProtein kinase inhibitorCSF1RCSF1R inhibitor
PKProtein kinase inhibitorEGFREGFR inhibitor.
PKProtein kinase inhibitorEIF2AK3EIF2AK3 inhibitor
PKProtein kinase inhibitorEPHA4EPHA4 inhibitor
PKProtein kinase inhibitorERBB2ERBB2 inhibitor
PKProtein kinase inhibitorERKERK inhibitor
PKProtein kinase inhibitorFAKFAK inhibitor
PKProtein kinase inhibitorFGFRFGFR inhibitor
PKProtein kinase inhibitorFGFR1FGFR1 inhibitor
PKProtein kinase inhibitorFGFR2FGFR2 inhibitor
PKProtein kinase inhibitorFGFR3FGFR3 inhibitor
PKProtein kinase inhibitorFGFR4FGFR4 inhibitor
PKProtein kinase inhibitorFLTFlt inhibitor (FLT1, FLT3, FLT4)
PKProtein kinase inhibitorFLT3FLT3 inhibitor
PKProtein kinase inhibitorFYNFYN inhibitor
PKProtein kinase inhibitorGSK3AGSK3A inhibitor
PKProtein kinase inhibitorGSK3BGSK3B inhibitor
PKProtein kinase inhibitorHCKHCK inhibitor
PKProtein kinase inhibitorIGF1RIGF1R inhibitor
PKProtein kinase inhibitorJAKJAK inhibitor
PKProtein kinase inhibitorJAK1JAK1 inhibitor
PKProtein kinase inhibitorJAK2JAK2 inhibitor
PKProtein kinase inhibitorJAK3JAK3 inhibitor
PKProtein kinase inhibitorKDRKDR inhibitor
PKProtein kinase inhibitorKITc-Kit inhibitor
PKProtein kinase inhibitorLCKLCK inhibitor
PKProtein kinase inhibitorLYNLYN inhibitor
PKProtein kinase inhibitorMAP2KMAP2K (MEK) inhibitor
PKProtein kinase inhibitorMAP2K1MAP2K1 inhibitor
PKProtein kinase inhibitorMAP2K2MAP2K2 inhibitor
PKProtein kinase inhibitorMAP3KMAP3K (ERK1) inhibitor
PKProtein kinase inhibitorMAP3K5MAP3K5 inhibitor
PKProtein kinase inhibitorMAPK1MAPK1 inhibitor
PKProtein kinase inhibitorMAPK14MAPK14 (p38) inhibitor
PKProtein kinase inhibitorMAPK8MAPK8 (JNK) inhibitor
PKProtein kinase inhibitorMELKMELK inhibitor
PKProtein kinase inhibitorMERTKMERTK inhibitor
PKProtein kinase inhibitorMETMET inhibitor
PKProtein kinase inhibitorMST1RMST1R inhibitor
PKProtein kinase inhibitorMTORMTOR inhibitor
PKProtein kinase inhibitorMultikinaseMultikinase inhibitor
PKProtein kinase inhibitorNot AvailableNot Available
PKProtein kinase inhibitorNTRKNTRK1, NTRK2 inhibitor
PKProtein kinase inhibitorPAK4PAK4 inhibitor
PKProtein kinase inhibitorPBKPBK inhibitor
PKProtein kinase inhibitorPDGFRPDGFR inhibitor
PKProtein kinase inhibitorPDK1PDK1 inhibitor
PKProtein kinase inhibitorPIK3Phosphoinositide-3-Kinase
PKProtein kinase inhibitorPIM1PIM1 inhibitor
PKProtein kinase inhibitorPIM2PIM2 inhibitor
PKProtein kinase inhibitorPIM3PIM3 inhibitor
PKProtein kinase inhibitorPLK1PLK1 inhibitor
PKProtein kinase inhibitorPRKCAPRKCA (PRK) inhibitor
PKProtein kinase inhibitorPRKDCPRKDC inhibitor
PKProtein kinase inhibitorPTKProtein tyrosine kinase (a gene name)
PKProtein kinase inhibitorRAFRAF inhibitor
PKProtein kinase inhibitorRAF1RAF1 inhibitor
PKProtein kinase inhibitorRETRET inhibitor
PKProtein kinase inhibitorRONRON inhibitor
PKProtein kinase inhibitorROS1ROS1 inhibitor
PKProtein kinase inhibitorSRCSRC inhibitor
PKProtein kinase inhibitorSTKSerine threonine kinase
PKProtein kinase inhibitorSYKSYK inhibitor
PKProtein kinase inhibitorTEKTEK inhibitor
PKProtein kinase inhibitorTNKSTNKS inhibitor
PKProtein kinase inhibitorTTKTTK inhibitor
PKProtein kinase inhibitorTYK2TYK2 inhibitor
PKProtein kinase inhibitorVEGFVEGF inhibitor
PKProtein kinase inhibitorVEGFRVEGFR inhibitor
PKProtein kinase inhibitorWEE1WEE1 inhibitor
PKProtein kinase inhibitorYES1YES1 inhibitor
PKProtein kinase inhibitorYKTyrosine kinase inhibitor
--A2Alkylating at N-2 position of guanine
--A6Alkylating at O-6 of guanine
--A7Alkylating at N-7 position of guanine
--AbAntibodies
--ADAAdenosine deaminase
--AEMDAltered energy metabolism drug
--AGPAT2AGPAT2 (LPAATB) inhibitor
--AlkAgAlkylating agent
--AMAntimetabolite
--AngAngiogenesis inhibitor
--anti-Hoanti-Hormone
--AOAntioxidant
--APAntiprotozoal
--APH1APH1A, APHiB gamma secretase inhibitors
--ApoApoptosis inducer
--ARAndrogen receptor
--BADBAD inhibitor
--BCL2BCL2 inhibitor
--BCR-ABLBCR-ABL inhibitor
--BIRC5BIRC5 inhibitor
--BRDBromodomain inhibiting
--CASPCaspase inhibitor
--CCCell cycle
--CCNT1CCNT1 inhibitor
--CD133CD133 inhibitor
--CDH16CDH16 (KSP) inhibitor
--CENPCENP inhibitor
--CK2Casein kinase 2 inhibitor
--CTNNB1Beta catenin inhibior
--CTSBCapthepsin inhibitor
--CXCR2CXCR2 inhibitor
--CXCR4CXCR4 inhibitor
--CYP11A1CYP11A1 inhibitor
--CYP17A1CYP17A1 inhibitor
--CYP19A1CYP19A1 (aromatase) inhibitor
--DbDNA binder
--DDIDNA damage inducer
--DDRDNA damage repair
--DfAntifols (impairs the function of folic acids. This inhibits production of DNA, RNA, and proteins)
--DHFRDHFR inhibitor
--DHODHDHODH inhibitor
--DifferentiatorCauses differentiation of progenitor cancer cells.
--DNMTDNA methylttransferase inhibitor
--DOT1LDOT1L inhibitor
--DrRibonucleotide reductase inhibitor
--DsDNA synthesis inhibitor
--EEDEED inhibitor
--EHMT1/2EHMT1/2 inhibitor
--EHMT2EHMT2 inhibitor
--EPAS1EPAS1 inhibitor
--ERSelective Estrogen Receptor Modulators
--ERGERG inhibitor
--ETVETV1 inhibitor
--EZH2EZH2 inhibitor
--F7F7 inhibitor
--FASFAS inhibitor
--FASNFASN inhibitor
--FGFFGF inhibitor
--FRSFree radical savenger
--FTFarnesel transferase inhibitor
--FU-Antidote5 fluorouracil antidote
--Gamma secretaseGamma secretase affector
--GARTFGARTF inhibitor
--GEMIN2GEMIN2 (SIP1) inhibitor
--GLSGLS inhibitor
--GSTP1GSTP1 inhibitor
--GTPaseRas, Raf and other GTPases
--HDACHistone deacetylase
--Hg-SmoHedgehog-Smoothen - B catenin
--HIF1HIF1 inhibitor
--HK2hexokinase II inhibitor
--HMGCS1/2HMGCS1/2 inhibitor
--Hohormone
--HPGDHPGD inhibitor
--HSP90HSP90(AA1, AB1)
--HYPHypoxia
--IAPXIAP, BIRC2,3,5,7,8
--IDH1IDH1 inhibitor
--IDH2IDH2 inhibitor
--IDNARepInhibitor of DNA replication
--IDO1IDO1 inhibitor
--IDUAIDUA inhibitor
--ILInterleukin
--IL6IL6 inhibitor
--ImmunomodulatoryImmunomodulatory
--IMPDHIMPDH inhibitor
--IMPDH1IMPDH1 inhibitor
--IMPDH2IMPDH2 inhibitor
--INDOIndoleamine 2,3-dioxygenase inhibitor
--ITGintegrin affector
--KDM1AKDM1A inhibitor
--KIF11KIF11 (Eg5) inhibitor
--KinesinKinesin spindle protein inhibitor
--KLF4KLF4 inhibitor
--KMT2AKMT2A inhibitor
--KRASKRAS inhibitor
--LDHALDHA inhibitor
--MCL1MCL1 inhibitor
--MDM2MDM2 inhibitor
--MGLLMGLL (MAGL) inhibitor
--MGMTMGMT inhibitor
--MitoMitochondria; Warburg effect
--MKNK1/2MKNK1/2 inhibitor
--MTF1MTF1 inhibitor
--MYCc-Myc inhibitor
--NAMPTNAMPT inhibitor
--NEDD8NEDD8 (NAE) inhibitor
--NFkBNuclear factor of kappa light polypeptide gene enhancer in B-cells
--NOTCHNOTCH inhibitor.
--NR1H1/2NR1H1/2 inhibitor
--PARPPoly(ADP-ribose)polymerase
--PARP1PARP1 inhibitor
--PARP2PARP2 inhibitor
--PasePhosphatase inhibitor
--PDPhosphodiesterase inhibitor
--PDE6DPDE6D (PDE delta) inhibitor
--PGRPGR inhibitor
--Piprotein synthesis inhibitor
--PI3KBPI3KB inhibitor
--PKMPKM (PKM2) inhibitor
--PORCNporcupine inhibitor
--PPARGPPARG inhibitor
--PPATPPAT inhibitor
--PRMT5PRMT5 inhibitor
--PRMT6PRMT6 inhibitor
--Protein kinase APKA inhibitor
--PSMproteasome inhibitor
--PTGS2PTGS2 inhibitor
--PYGLPYGL inhibitor
--RAD51RAD51 inhibitor
--RASRAS inhibitor
--RASA1RASA1 inhibitor
--RDIRNA damage inducer
--RHORHO inhibitor
--RNA polymerase IRNA polymerase I inhibitor
--RPRadioprotectant
--RPS6RPS6 inhibitor
--RsRNA synthesis inhibitor
--RXRRetinoic acid receptor
--SERDSelective estrogen receptor degrader
--SERMSelective estrogen receptor modulator
--SETD8SETD8 (N-Lysine Methyltransferase) inhibitor
--SLC16A1SLC16A1 inhibitor
--SLC16A7SLC16A7 inhibitor
--SLC2A1SLC2A1 inhibitor
--SMOSMO inhibitor
--SMYD2SMYD2 inhibitor
--SMYD3SMYD3 inhibitor
--SPHK2SPHK2 inhibitor
--STATSTAT(3,5) inhibitor
--STAT3STAT3 inhibitor
--STAT5A/BSTAT5A/B inhibitor
--TGFB1TGFB1 inhibitor
--TLR7TLR7 inhibitor
--TLR8TLR8 inhibitor
--TOP1Topoisomerase 1 inhibitor
--TOP2Topoisomerase 2 inhibitor
--TuTubulin affecting
--Tu-fragTubulin fragmenter
--Tu-stabTubulin stabilizer
--TXNRDTXNRD (1,2,3) inhibitor
--TYMSTYMS inhibitor
--UB-activatingUbiquitin-activating enzyme
--VCPVCP inhibitor
--VHLVHL inhibitor
--WDR5WDR5 inhibitor
--WntWingless-type MMTV integration site family (WNT) inhibitor
--XDHXDH inhibitor
--XPO1XPO1 inhibitor
--YWHAYWHA antagonist

(a) Mechanisms of action for a subset of these is available at http://dtp.nci.nih.gov/docs/cancer/searches/standard_mechanism_list.html