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CellMiner Address: https://discover.nci.nih.gov/cellminer/
CellMiner Database Version: 2.5
Human Genome Version: HG-19
Date: 01-26-2021
Table 11: Genes with reverse phase protein array (RPPA) data
Gene symbolAnnotations
ACVR2Aregulation of BMP signaling pathway; activin receptor signaling pathway; positive regulation of activin receptor signaling pathway; sperm ejaculation; penile erection; positive regulation of erythrocyte differentiation; positive regulation of osteoblast differentiation; positive regulation of follicle-stimulating hormone secretion; embryonic skeletal system development; regulation of nitric-oxide synthase activity; anterior/posterior pattern specification; Sertoli cell proliferation; positive regulation of bone mineralization; response to organic substance; BMP signaling pathway; mesoderm development; determination of left/right symmetry; spermatogenesis; transmembrane receptor protein serine/threonine kinase signaling pathway; positive regulation of protein phosphorylation; gastrulation with mouth forming second
ADNPneuroprotection; nitric oxide homeostasis; estrous cycle phase; positive regulation of synapse assembly; negative regulation of synaptic transmission; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of axon extension; response to carbohydrate stimulus; short-term memory; negative regulation of neuron apoptosis; activation of protein kinase activity; negative regulation of protein binding; cellular response to extracellular stimulus; positive regulation of cGMP biosynthetic process; positive regulation of neuron projection development; regulation of protein ADP-ribosylation; negative regulation of gene expression; response to inorganic substance
AKAP5signal transduction; protein targeting; energy reserve metabolic process; synaptic transmission; positive regulation of protein kinase A signaling cascade; positive regulation of cAMP biosynthetic process; small molecule metabolic process; regulation of insulin secretion
AKAP8mitosis; mitotic chromosome condensation; signal transduction
ANXA1peptide cross-linking; cell cycle; insulin secretion; keratinocyte differentiation; response to interleukin-1; endocrine pancreas development; positive regulation of vesicle fusion; positive regulation of prostaglandin biosynthetic process; response to estradiol stimulus; gliogenesis; regulation of cell proliferation; response to drug; positive regulation of apoptotic process; negative regulation of apoptotic process; response to peptide hormone stimulus; alpha-beta T cell differentiation; arachidonic acid secretion; negative regulation of protein secretion; response to glucocorticoid stimulus; estrous cycle phase; cellular response to hydrogen peroxide; hepatocyte differentiation; response to X-ray; response to organic cyclic compound; negative regulation of acute inflammatory response; lipid metabolic process; anti-apoptosis; cellular component movement; inflammatory response; signal transduction; cell surface receptor signaling pathway
ANXA2angiogenesis; cellular response to acid; body fluid secretion; collagen fibril organization; positive regulation of vesicle fusion; fibrinolysis; positive regulation of binding; skeletal system development
ANXA4anti-apoptosis; signal transduction; negative regulation of coagulation
AP2M1synaptic transmission; regulation of defense response to virus by virus; nerve growth factor receptor signaling pathway; negative regulation of epidermal growth factor receptor signaling pathway; vesicle-mediated transport; cellular membrane organization; viral reproduction; axon guidance; epidermal growth factor receptor signaling pathway; intracellular protein transport; transport
ATXN2homeostasis of number of cells; RNA transport; neuromuscular process; neuron projection morphogenesis; negative regulation of multicellular organism growth; stress granule assembly; cerebellar Purkinje cell differentiation; RNA metabolic process; regulation of translation; cell death; cytoplasmic mRNA processing body assembly
BCAR1integrin-mediated signaling pathway; G-protein coupled receptor signaling pathway; epidermal growth factor receptor signaling pathway; cell chemotaxis; cell division; B cell receptor signaling pathway; T cell receptor signaling pathway; antigen receptor-mediated signaling pathway; signal transduction; cell adhesion; hepatocyte growth factor receptor signaling pathway; actin filament organization; regulation of cell growth; nerve growth factor receptor signaling pathway; vascular endothelial growth factor receptor signaling pathway; platelet-derived growth factor receptor signaling pathway; regulation of apoptotic process; cellular response to hepatocyte growth factor stimulus; positive regulation of cell migration; platelet activation; cell migration; insulin receptor signaling pathway; cell proliferation; blood coagulation
CASP2apoptotic signaling pathway; execution phase of apoptosis; cellular response to mechanical stimulus; nerve growth factor receptor signaling pathway; positive regulation of neuron apoptosis; positive regulation of apoptotic process; protein processing; induction of apoptosis by extracellular signals; aging; metabolic process; luteolysis; neural retina development; proteolysis; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; apoptotic process; brain development
CASP7induction of apoptosis; positive regulation of neuron apoptosis; protein processing; response to UV; activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c; induction of apoptosis by intracellular signals; aging; heart development; cellular component disassembly involved in apoptosis; apoptotic process; proteolysis; release of cytochrome c from mitochondria
CCNA2mitotic cell cycle; regulation of cyclin-dependent protein kinase activity; G2/M transition of mitotic cell cycle; mitosis; mitotic cell cycle G2/M transition DNA damage checkpoint; Ras protein signal transduction; positive regulation of transcription, DNA-dependent; cell division
CCNB1protein complex assembly; cell cycle checkpoint; negative regulation of protein phosphorylation; in utero embryonic development; oocyte maturation; mitotic cell cycle; mitotic prometaphase; G2/M transition of mitotic cell cycle; G1/S transition of mitotic cell cycle; regulation of cyclin-dependent protein kinase activity; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; positive regulation of cardiac muscle cell proliferation; ventricular cardiac muscle cell development; positive regulation of attachment of spindle microtubules to kinetochore; regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; cell division; digestive tract development; response to DDT; positive regulation of mitotic cell cycle; mitotic spindle stabilization; response to drug; tissue regeneration; positive regulation of histone phosphorylation; positive regulation of mRNA 3'-end p
CD46interspecies interaction between organisms; complement activation, classical pathway; innate immune response; single fertilization
CDH1apoptotic process; cellular response to lithium ion; cellular response to indole-3-methanol; cellular component disassembly involved in apoptosis; cell adhesion; homophilic cell adhesion; synapse assembly; response to toxin; response to organic substance; cell-cell adhesion; pituitary gland development; neuron projection development; cell junction assembly; adherens junction organization; response to drug; positive regulation of transcription factor import into nucleus; cell-cell junction organization; positive regulation of transcription, DNA-dependent; regulation of immune response; negative regulation of cell-cell adhesion
CDH2regulation of axonogenesis; adherens junction organization; cell junction assembly; regulation of protein localization; regulation of myelination; cell migration; calcium-dependent cell-cell adhesion; synapse assembly; heterophilic cell-cell adhesion; homophilic cell adhesion; cell adhesion; regulation of Rho protein signal transduction; muscle cell differentiation; positive regulation of MAPK cascade; cell-cell junction organization; blood vessel morphogenesis; striated muscle cell differentiation; positive regulation of muscle cell differentiation; negative regulation of canonical Wnt receptor signaling pathway
CDH3adherens junction organization; cell adhesion; cell-cell junction organization; response to stimulus; homophilic cell adhesion; visual perception; cell junction assembly
CDK1response to drug; positive regulation of gene expression; protein localization to kinetochore; toll-like receptor 4 signaling pathway; toll-like receptor 3 signaling pathway; toll-like receptor 2 signaling pathway; toll-like receptor 1 signaling pathway; positive regulation of protein import into nucleus, translocation; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; organ regeneration; chromosome condensation; cell migration; response to activity; response to amine stimulus; response to organic cyclic compound; regulation of Schwann cell differentiation; TRIF-dependent toll-like receptor signaling pathway; innate immune response; response to ethanol; positive regulation of DNA replication; positive regulation of mitotic cell cycle; regulation of embryonic development; response to cadmium ion; response to copper ion; nerve growth factor receptor signaling pathway; response to axon injury; cell division; stress-activated MAPK cascade; positive regulation of ubiqu
CDK4positive regulation of fibroblast proliferation; regulation of cell cycle; cell division; response to drug; regulation of gene expression; positive regulation of cell proliferation; signal transduction; protein phosphorylation; mitotic cell cycle; S phase of mitotic cell cycle; cell cycle; G1/S transition of mitotic cell cycle; G1 phase of mitotic cell cycle
CDK5negative regulation of transcription, DNA-dependent; positive regulation of protein kinase activity; negative regulation of cell cycle; regulated secretory pathway; positive regulation of neuron apoptosis; receptor clustering; regulation of apoptotic process; synaptic transmission, glutamatergic; serine phosphorylation of STAT3 protein; receptor catabolic process; negative regulation of synaptic plasticity; negative regulation of protein ubiquitination; neuron projection development; cortical actin cytoskeleton organization; central nervous system neuron development; regulation of cell migration; positive regulation of calcium ion-dependent exocytosis; protein autophosphorylation; negative regulation of protein export from nucleus; behavioral response to cocaine; regulation of synaptic plasticity; synaptic vesicle endocytosis; axon extension; oligodendrocyte differentiation; dendrite morphogenesis; cell division; neuron apoptosis; regulation of excitatory postsynaptic membrane potential; regulation of dendrit
CDK6hemopoiesis; lateral ventricle development; dentate gyrus development; astrocyte development; regulation of gene expression; response to virus; negative regulation of cell proliferation; cell cycle arrest; cell cycle; protein phosphorylation; type B pancreatic cell development; positive regulation of cell-matrix adhesion; mitotic cell cycle; G1/S transition of mitotic cell cycle; G1 phase of mitotic cell cycle; regulation of erythrocyte differentiation; cell dedifferentiation; gliogenesis; negative regulation of cellular senescence; regulation of cell motility; cell division; negative regulation of epithelial cell proliferation; generation of neurons; negative regulation of cell cycle; negative regulation of osteoblast differentiation; negative regulation of myeloid cell differentiation; negative regulation of cell differentiation; positive regulation of fibroblast proliferation
CDK7transcription from RNA polymerase II promoter; mRNA capping; transcription initiation from RNA polymerase II promoter; transcription elongation from RNA polymerase II promoter; protein phosphorylation; cell cycle arrest; cell proliferation; gene expression; viral reproduction; androgen receptor signaling pathway; positive regulation of transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter; positive regulation of viral transcription; cell division; transcription elongation from RNA polymerase I promoter; regulation of cyclin-dependent protein kinase activity; G1 phase of mitotic cell cycle; G1/S transition of mitotic cell cycle; S phase of mitotic cell cycle; G2/M transition of mitotic cell cycle; mitotic cell cycle; DNA repair; transcription-coupled nucleotide-excision repair; nucleotide-excision repair; transcription from RNA polymerase I promoter; transcription initiation from RNA polymerase I promoter; termination of RNA polymerase I transcription; nucleotide-ex
CDKN2Anegative regulation of B cell proliferation; protein destabilization; negative regulation of cell growth; regulation of G2/M transition of mitotic cell cycle; apoptotic mitochondrial changes; negative regulation of cell proliferation; Ras protein signal transduction; cell cycle arrest; cell cycle; activation of cysteine-type endopeptidase activity involved in apoptotic process; induction of apoptosis; negative regulation of protein kinase activity; rRNA processing; DNA fragmentation involved in apoptotic nuclear change; negative regulation of cell-matrix adhesion; mitotic cell cycle; protein polyubiquitination; G1/S transition of mitotic cell cycle; G1 phase of mitotic cell cycle; cell cycle checkpoint; negative regulation of NF-kappaB transcription factor activity; positive regulation of cellular senescence; positive regulation of macrophage apoptosis; replicative senescence; cellular senescence; positive regulation of cell cycle arrest; protein K63-linked ubiquitination; negative regulation of ubiquitin-pro
CRKplatelet activation; ephrin receptor signaling pathway; nerve growth factor receptor signaling pathway; regulation of Rac protein signal transduction; regulation of actin cytoskeleton organization; regulation of Rho GTPase activity; insulin receptor signaling pathway; blood coagulation; regulation of transcription from RNA polymerase II promoter; activation of MAPKK activity
CTNNB1cell maturation; oviduct development; synaptic vesicle transport; thymus development; embryonic hindlimb morphogenesis; oocyte development; embryonic foregut morphogenesis; regulation of smooth muscle cell proliferation; negative regulation of oligodendrocyte differentiation; synapse organization; smooth muscle cell differentiation; positive regulation of muscle cell differentiation; determination of dorsal/ventral asymmetry; regulation of fibroblast proliferation; response to cadmium ion; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; negative regulation of transcription, DNA-dependent; positive regulation of anti-apoptosis; regulation of angiogenesis; positive regulation of fibroblast growth factor receptor signaling pathway; negative regulation of osteoclast differentiation; positive regulation of osteoblast differentiation; positive regulation of endothelial cell differentiation; bone resorption; canonical Wnt receptor signaling p
CTTN-
DSG1apoptotic process; cellular component disassembly involved in apoptosis; cell-cell junction assembly; homophilic cell adhesion; cell-cell adhesion; calcium-dependent cell-cell adhesion; protein stabilization
ENAHT cell receptor signaling pathway; intracellular transport; actin polymerization or depolymerization; axon guidance; cellular component movement; neural tube closure
EP300response to calcium ion; response to glucocorticoid stimulus; regulation of angiotensin metabolic process; positive regulation of sarcomere organization; regulation of androgen receptor signaling pathway; protein-DNA complex assembly; cellular response to hydrogen peroxide; response to fatty acid; skeletal muscle tissue development; heart development; nervous system development; cell cycle; apoptotic process; regulation of transcription, DNA-dependent; positive regulation of protein phosphorylation; liver development; somitogenesis; response to hypoxia; negative regulation of transcription from RNA polymerase II promoter; negative regulation of cellular metabolic process; DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis; response to drug; positive regulation of protein import into nucleus, translocation; positive regulation of collagen biosynthetic process; response to retinoic acid; positive regulation of protein binding; response to cobalt ion; positive regu
ERBB2protein autophosphorylation; phosphatidylinositol-mediated signaling; sympathetic nervous system development; response to axon injury; positive regulation of epithelial cell proliferation; mammary gland involution; estrus; regulation of ERK1 and ERK2 cascade; negative regulation of apoptotic process; motor axon guidance; positive regulation of Ras protein signal transduction; response to progesterone stimulus; regulation of microtubule-based process; negative regulation of immature T cell proliferation in thymus; wound healing; response to drug; myelination; positive regulation of Rho GTPase activity; mammary gland development; positive regulation of cell growth; signal transduction by phosphorylation; positive regulation of phosphatidylinositol 3-kinase cascade; phosphatidylinositol 3-kinase cascade; glial cell differentiation; cell proliferation; positive regulation of transcription from RNA polymerase III promoter; neuromuscular junction development; skeletal muscle tissue development; heart development; p
ESR1intracellular estrogen receptor signaling pathway; cellular response to estrogen stimulus; positive regulation of ERK1 and ERK2 cascade; epithelial cell proliferation involved in mammary gland duct elongation; mammary gland alveolus development; mammary gland branching involved in pregnancy; regulation of branching involved in prostate gland morphogenesis; prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis; regulation of apoptotic process; prostate epithelial cord elongation; antral ovarian follicle growth; epithelial cell development; osteoblast development; transcription, DNA-dependent; regulation of transcription, DNA-dependent; signal transduction; androgen metabolic process; gene expression; negative regulation of gene expression; response to estradiol stimulus; vagina development; negative regulation of I-kappaB kinase/NF-kappaB cascade; steroid hormone mediated signaling pathway; negative regulation of sequence-specific DNA binding transcription factor activity; n
EXOC4oligodendrocyte differentiation; positive regulation of calcium-mediated signaling; regulation of protein transport; membrane biogenesis; establishment of cell polarity; Golgi to transport vesicle transport; synaptic transmission; vesicle docking involved in exocytosis; protein targeting to membrane
EZRactin filament bundle assembly; epithelial cell differentiation; membrane to membrane docking; regulation of cell shape; axon guidance; establishment or maintenance of apical/basal cell polarity; cytoskeletal anchoring at plasma membrane; leukocyte cell-cell adhesion
FADDapoptotic process; innate immune response; necrotic cell death; cellular response to mechanical stimulus; extrinsic apoptotic signaling pathway; positive regulation of extrinsic apoptotic signaling pathway; positive regulation of type I interferon-mediated signaling pathway; defense response to virus; positive regulation of transcription from RNA polymerase II promoter; interspecies interaction between organisms; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of apoptotic process; positive regulation of tumor necrosis factor production; positive regulation of interleukin-8 production; activation of pro-apoptotic gene products; induction of apoptosis via death domain receptors; induction of apoptosis by extracellular signals; signal transduction; activation of cysteine-type endopeptidase activity involved in apoptotic process
FASLGpositive regulation of epidermal growth factor receptor signaling pathway; cellular response to stress; positive regulation of neuron apoptosis; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of apoptotic process; inflammatory cell apoptosis; retinal cell programmed cell death; endosomal lumen acidification; induction of necroptosis of activated-T cells; induction of necroptosis by extracellular signals; necrotic cell death; response to growth factor stimulus; cellular chloride ion homeostasis; negative regulation of angiogenesis; activation of pro-apoptotic gene products; induction of apoptosis via death domain receptors; induction of apoptosis by extracellular signals; positive regulation of cell proliferation; response to lipopolysaccharide; immune response; activation of cysteine-type endopeptidase activity involved in apoptotic process; induction of apoptosis; apoptotic process; cell-cell signaling; signal transduction
FN1acute-phase response; leukocyte migration; substrate adhesion-dependent cell spreading; platelet activation; peptide cross-linking; cell migration; response to wounding; blood coagulation; cell adhesion; regulation of cell shape; platelet degranulation; angiogenesis
GRB2regulation of MAPK cascade; epidermal growth factor receptor signaling pathway; signal transduction in response to DNA damage; interspecies interaction between organisms; nerve growth factor receptor signaling pathway; negative regulation of epidermal growth factor receptor signaling pathway; receptor internalization; T cell costimulation; platelet activation; anatomical structure formation involved in morphogenesis; leukocyte migration; protein heterooligomerization; branching involved in embryonic placenta morphogenesis; cellular response to ionizing radiation; positive regulation of reactive oxygen species metabolic process; cell differentiation; fibroblast growth factor receptor signaling pathway; Ras protein signal transduction; cell-cell signaling; axon guidance; aging; insulin receptor signaling pathway; blood coagulation
GSK3Bregulation of microtubule-based process; intracellular signal transduction; negative regulation of apoptotic process; negative regulation of signal transduction; negative regulation of glycogen biosynthetic process; positive regulation of protein catabolic process; positive regulation of protein export from nucleus; nerve growth factor receptor signaling pathway; phosphatidylinositol-mediated signaling; negative regulation of NFAT protein import into nucleus; canonical Wnt receptor signaling pathway; superior temporal gyrus development; negative regulation of canonical Wnt receptor signaling pathway; negative regulation of type B pancreatic cell development; negative regulation of glycogen (starch) synthase activity; nervous system development; epithelial to mesenchymal transition; positive regulation of cell-matrix adhesion; carbohydrate metabolic process; glycogen metabolic process; protein phosphorylation; ER overload response; epidermal growth factor receptor signaling pathway; multicellular organismal de
GSTP1negative regulation of leukocyte proliferation; cellular response to lipopolysaccharide; cellular response to epidermal growth factor stimulus; cellular response to glucocorticoid stimulus; cellular response to cell-matrix adhesion; negative regulation of monocyte chemotactic protein-1 production; negative regulation of MAPK cascade; positive regulation of superoxide anion generation; response to L-ascorbic acid; common myeloid progenitor cell proliferation; nitric oxide storage; regulation of phosphorylation; negative regulation of apoptotic process; negative regulation of I-kappaB kinase/NF-kappaB cascade; response to amino acid stimulus; negative regulation of MAP kinase activity; negative regulation of acute inflammatory response; negative regulation of JUN kinase activity; small molecule metabolic process; response to ethanol; negative regulation of fibroblast proliferation; negative regulation of nitric-oxide synthase biosynthetic process; negative regulation of necrotic cell death; regulation of ERK1 a
GTF2Bgene expression; interspecies interaction between organisms; viral reproduction; transcription elongation from RNA polymerase II promoter; transcription initiation from RNA polymerase II promoter; transcription from RNA polymerase II promoter; regulation of transcription, DNA-dependent
HRAScellular senescence; positive regulation of DNA replication; MAPK cascade; activation of MAPKK activity; positive regulation of protein phosphorylation; endocytosis; apoptotic process; chemotaxis; cell cycle arrest; visual learning; positive regulation of JNK cascade; signal transduction; cell surface receptor signaling pathway; epidermal growth factor receptor signaling pathway; small GTPase mediated signal transduction; Ras protein signal transduction; synaptic transmission; axon guidance; blood coagulation; positive regulation of cell proliferation; negative regulation of cell proliferation; insulin receptor signaling pathway; nerve growth factor receptor signaling pathway; fibroblast growth factor receptor signaling pathway; induction of apoptosis by intracellular signals; organ morphogenesis; actin cytoskeleton organization; mitotic cell cycle G1/S transition checkpoint; regulation of synaptic transmission, GABAergic; positive regulation of Rac protein signal transduction; social behavior; positive regul
HSPA4response to stress; response to unfolded protein; response to heat; positive regulation of protein binding; protein import into mitochondrial outer membrane; chaperone-mediated protein complex assembly
HSPD1negative regulation of apoptotic process; B cell cytokine production; MyD88-dependent toll-like receptor signaling pathway; positive regulation of T cell mediated immune response to tumor cell; ATP catabolic process; 'de novo' protein folding; activation of cysteine-type endopeptidase activity involved in apoptotic process; response to unfolded protein; cell death; positive regulation of interferon-gamma production; positive regulation of macrophage activation; B cell activation; T cell activation; B cell proliferation; protein maturation; chaperone-mediated protein complex assembly; positive regulation of T cell activation; protein stabilization; positive regulation of interferon-alpha production; isotype switching to IgG isotypes; interspecies interaction between organisms; positive regulation of apoptotic process; protein refolding; positive regulation of interleukin-6 production; positive regulation of interleukin-10 production; positive regulation of interleukin-12 production
IRF9regulation of transcription, DNA-dependent; type I interferon-mediated signaling pathway; interferon-gamma-mediated signaling pathway; type I interferon biosynthetic process; cytokine-mediated signaling pathway; response to virus; cell surface receptor signaling pathway; transcription from RNA polymerase II promoter
IRS1cellular response to insulin stimulus; positive regulation of phosphorylation; protein localization to nucleus; response to insulin stimulus; positive regulation of fatty acid beta-oxidation; mammary gland development; positive regulation of cell migration; lipid catabolic process; phosphatidylinositol 3-kinase cascade; positive regulation of glucose metabolic process; regulation of gene expression; insulin receptor signaling pathway; positive regulation of cell proliferation; transmembrane receptor protein tyrosine kinase signaling pathway; signal transduction; positive regulation of mesenchymal cell proliferation; negative regulation of insulin receptor signaling pathway; glucose homeostasis; response to peptide hormone stimulus; protein kinase B signaling cascade; positive regulation of phosphatidylinositol 3-kinase activity; positive regulation of glycogen biosynthetic process; positive regulation of glucose import; negative regulation of somatostatin secretion; positive regulation of glucagon secretion;
JAK1cytokine-mediated signaling pathway; regulation of type I interferon-mediated signaling pathway; type I interferon-mediated signaling pathway; regulation of interferon-gamma-mediated signaling pathway; interferon-gamma-mediated signaling pathway; response to antibiotic; intracellular signal transduction; peptidyl-tyrosine phosphorylation; intracellular protein kinase cascade; enzyme linked receptor protein signaling pathway; protein phosphorylation
KLK3proteolysis; negative regulation of angiogenesis
KRT18anatomical structure morphogenesis; tumor necrosis factor-mediated signaling pathway; Golgi to plasma membrane CFTR protein transport; negative regulation of apoptotic process; interspecies interaction between organisms; cell cycle
KRT19cell differentiation involved in embryonic placenta development; interspecies interaction between organisms; sarcomere organization; response to estrogen stimulus
KRT20apoptotic process; regulation of protein secretion; intermediate filament organization; cellular response to stress
KRT7interphase; interspecies interaction between organisms; cytoskeleton organization; regulation of translation; DNA replication
KRT8interspecies interaction between organisms; cytoskeleton organization
MAP2K1negative regulation of cell proliferation; cell cycle arrest; mitosis; signal transduction; epidermal growth factor receptor signaling pathway; small GTPase mediated signal transduction; Ras protein signal transduction; axon guidance; Toll signaling pathway; regulation of vascular smooth muscle contraction; insulin receptor signaling pathway; response to oxidative stress; chemotaxis; cellular component movement; neuron differentiation; MyD88-independent toll-like receptor signaling pathway; MyD88-dependent toll-like receptor signaling pathway; toll-like receptor signaling pathway; activation of MAPK activity; activation of MAPKK activity; MAPK cascade; placenta blood vessel development; TRIF-dependent toll-like receptor signaling pathway; cellular senescence; regulation of Golgi inheritance; labyrinthine layer development; stress-activated MAPK cascade; response to glucocorticoid stimulus; cell motility; neuron projection morphogenesis; response to axon injury; nerve growth factor receptor signaling pathway;
MAP2K2toll-like receptor 1 signaling pathway; MyD88-dependent toll-like receptor signaling pathway; MyD88-independent toll-like receptor signaling pathway; protein phosphorylation; epidermal growth factor receptor signaling pathway; small GTPase mediated signal transduction; Ras protein signal transduction; axon guidance; regulation of early endosome to late endosome transport; positive regulation of cell motility; regulation of Golgi inheritance; ERK1 and ERK2 cascade; stress-activated MAPK cascade; nerve growth factor receptor signaling pathway; activation of MAPK activity; toll-like receptor signaling pathway; toll-like receptor 3 signaling pathway; toll-like receptor 2 signaling pathway; Toll signaling pathway; insulin receptor signaling pathway; fibroblast growth factor receptor signaling pathway; regulation of stress-activated MAPK cascade; toll-like receptor 4 signaling pathway; TRIF-dependent toll-like receptor signaling pathway; innate immune response; MAPK cascade; activation of MAPKK activity
MAPK1stress-activated MAPK cascade; regulation of cytoskeleton organization; JAK-STAT cascade involved in growth hormone signaling pathway; labyrinthine layer blood vessel development; ERK1 and ERK2 cascade; caveolin-mediated endocytosis; regulation of Golgi inheritance; regulation of early endosome to late endosome transport; lipopolysaccharide-mediated signaling pathway; cell cycle; response to toxin; fibroblast growth factor receptor signaling pathway; insulin receptor signaling pathway; positive regulation of cell proliferation; Toll signaling pathway; blood coagulation; axon guidance; synaptic transmission; Ras protein signal transduction; small GTPase mediated signal transduction; epidermal growth factor receptor signaling pathway; signal transduction; B cell receptor signaling pathway; response to DNA damage stimulus; response to stress; chemotaxis; induction of apoptosis; apoptotic process; MyD88-independent toll-like receptor signaling pathway; MyD88-dependent toll-like receptor signaling pathway; toll-li
MCCsignal transduction; negative regulation of epithelial cell migration; Wnt receptor signaling pathway; negative regulation of epithelial cell proliferation; negative regulation of canonical Wnt receptor signaling pathway
MCM7cell cycle checkpoint; regulation of phosphorylation; cell proliferation; response to DNA damage stimulus; DNA strand elongation involved in DNA replication; DNA-dependent DNA replication initiation; DNA unwinding involved in replication; DNA replication; mitotic cell cycle; M/G1 transition of mitotic cell cycle; S phase of mitotic cell cycle; G1/S transition of mitotic cell cycle
MGMTDNA ligation; cellular response to organic cyclic compound; cellular response to ionizing radiation; mammary gland epithelial cell differentiation; negative regulation of cell death; response to folic acid; positive regulation of DNA repair; response to ethanol; regulation of cysteine-type endopeptidase activity involved in apoptotic process; response to drug; methylation; response to toxin; DNA dealkylation involved in DNA repair; DNA methylation; DNA repair; cellular response to oxidative stress
MLH1resolution of meiotic recombination intermediates; cellular response to organic cyclic compound; spindle midzone assembly involved in meiosis; oogenesis; negative regulation of mitotic recombination; isotype switching; meiotic metaphase I plate congression; response to drug; somatic hypermutation of immunoglobulin genes; DNA damage response, signal transduction resulting in induction of apoptosis; nuclear-transcribed mRNA poly(A) tail shortening; pachytene; response to toxin; response to hypoxia; ATP catabolic process; mismatch repair; double-strand break repair via nonhomologous end joining; cell cycle; male meiosis chromosome segregation; reciprocal meiotic recombination; spermatogenesis
MSH2double-strand break repair; response to UV-B; response to amino acid stimulus; DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis; response to drug; intra-S DNA damage checkpoint; B cell differentiation; B cell mediated immunity; somatic recombination of immunoglobulin gene segments; somatic hypermutation of immunoglobulin genes; response to organic cyclic compound; negative regulation of neuron apoptosis; response to X-ray; male gonad development; determination of adult lifespan; spermatogenesis; germ cell development; cell cycle arrest; meiotic gene conversion; postreplication repair; mismatch repair; maintenance of DNA repeat elements; negative regulation of reciprocal meiotic recombination; isotype switching; negative regulation of DNA recombination; positive regulation of helicase activity; meiotic mismatch repair; in utero embryonic development; oxidative phosphorylation; ATP catabolic process; DNA repair
MSH6mismatch repair; reciprocal meiotic recombination; determination of adult lifespan; induction of apoptosis by intracellular signals; DNA damage response, signal transduction resulting in induction of apoptosis; response to UV; somatic hypermutation of immunoglobulin genes; DNA repair; somatic recombination of immunoglobulin gene segments; maintenance of DNA repeat elements; ATP catabolic process; meiotic mismatch repair; positive regulation of helicase activity; negative regulation of DNA recombination; isotype switching
MSNmembrane to membrane docking; regulation of lymphocyte migration; leukocyte migration; cellular component movement; leukocyte cell-cell adhesion
MVPresponse to drug; mRNA transport; protein transport
NCAM1interferon-gamma-mediated signaling pathway; positive regulation of calcium-mediated signaling; homotypic cell-cell adhesion; cytokine-mediated signaling pathway; axon guidance; cell adhesion
NME1endocytosis; negative regulation of myeloid leukocyte differentiation; nucleoside diphosphate phosphorylation; GTP biosynthetic process; UTP biosynthetic process; nucleobase-containing small molecule metabolic process; response to cAMP; positive regulation of epithelial cell proliferation; small molecule metabolic process; positive regulation of DNA binding; regulation of apoptotic process; response to drug; cell differentiation; nucleobase-containing small molecule interconversion; nucleotide metabolic process; negative regulation of cell proliferation; lactation; nervous system development; CTP biosynthetic process
PARP1telomere maintenance; DNA repair; base-excision repair; regulation of transcription, DNA-dependent; transcription from RNA polymerase II promoter; protein autoprocessing; cellular response to insulin stimulus; regulation of growth rate; DNA damage response, detection of DNA damage; protein poly-ADP-ribosylation; protein ADP-ribosylation
PCNAS phase of mitotic cell cycle; G1/S transition of mitotic cell cycle; phosphatidylinositol-mediated signaling; response to cadmium ion; response to lipid; telomere maintenance via semi-conservative replication; positive regulation of deoxyribonuclease activity; translesion synthesis; cell proliferation; intracellular protein transport; regulation of transcription involved in G1/S phase of mitotic cell cycle; negative regulation of transcription from RNA polymerase II promoter; mitotic cell cycle; telomere maintenance via recombination; telomere maintenance; DNA replication; DNA strand elongation involved in DNA replication; regulation of DNA replication; DNA repair; transcription-coupled nucleotide-excision repair; base-excision repair; base-excision repair, gap-filling; nucleotide-excision repair; nucleotide-excision repair, DNA gap filling; mismatch repair; heart development
PGRregulation of epithelial cell proliferation; progesterone receptor signaling pathway; tertiary branching involved in mammary gland duct morphogenesis; steroid hormone mediated signaling pathway; mammary gland development; negative regulation of gene expression; cell-cell signaling; signal transduction; epithelial cell maturation; ovulation from ovarian follicle; gene expression
PRKCAnegative regulation of glial cell apoptosis; histone H3-T6 phosphorylation; intracellular signal transduction; positive regulation of blood vessel endothelial cell migration; small molecule metabolic process; positive regulation of lipopolysaccharide-mediated signaling pathway; positive regulation of macrophage differentiation; positive regulation of angiogenesis; positive regulation of cell adhesion; positive regulation of mitotic cell cycle; nerve growth factor receptor signaling pathway; regulation of insulin secretion; positive regulation of ERK1 and ERK2 cascade; response to interleukin-1; regulation of platelet aggregation; positive regulation of dense core granule biogenesis; induction of apoptosis by extracellular signals; mRNA metabolic process; platelet activation; positive regulation of endothelial cell proliferation; energy reserve metabolic process; protein phosphorylation; apoptotic process; signal transduction; epidermal growth factor receptor signaling pathway; activation of phospholipase C ac
PRKCBpositive regulation of angiogenesis; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of B cell receptor signaling pathway; lipoprotein transport; B cell activation; intracellular signal transduction; histone H3-T6 phosphorylation; positive regulation of vascular endothelial growth factor receptor signaling pathway; platelet activation; chromatin modification; negative regulation of glucose transport; blood coagulation; synaptic transmission; signal transduction; apoptotic process; protein phosphorylation; regulation of transcription from RNA polymerase II promoter; B cell receptor signaling pathway; positive regulation of NF-kappaB transcription factor activity; negative regulation of insulin receptor signaling pathway
PRKCHsignal transduction; regulation of tight junction assembly; positive regulation of glial cell proliferation; positive regulation of NF-kappaB transcription factor activity; positive regulation of B cell receptor signaling pathway; positive regulation of keratinocyte differentiation; intracellular signal transduction; platelet activation; cell differentiation; positive regulation of macrophage derived foam cell differentiation; blood coagulation; protein phosphorylation; negative regulation of glial cell apoptosis
PRKCInegative regulation of neuron apoptosis; establishment of apical/basal cell polarity; establishment or maintenance of epithelial cell apical/basal polarity; cell-cell junction organization; positive regulation of glucose import; secretion; nerve growth factor receptor signaling pathway; Golgi vesicle budding; positive regulation of NF-kappaB transcription factor activity; positive regulation of glial cell proliferation; response to interleukin-1; tight junction assembly; positive regulation of establishment of protein localization in plasma membrane; positive regulation of endothelial cell apoptosis; response to peptide hormone stimulus; eye photoreceptor cell development; intracellular signal transduction; negative regulation of glial cell apoptosis; cell junction assembly; cellular response to insulin stimulus; vesicle-mediated transport; cellular membrane organization; positive regulation of neuron projection development; actin filament organization; cytoskeleton organization; anti-apoptosis; protein targe
PRSS8proteolysis; response to mineralocorticoid stimulus; response to peptide hormone stimulus; response to drug; positive regulation of sodium ion transport; hair follicle development
PTPN11epidermal growth factor receptor signaling pathway; interferon-gamma-mediated signaling pathway; regulation of interferon-gamma-mediated signaling pathway; leukocyte migration; blood coagulation; insulin receptor signaling pathway; fibroblast growth factor receptor signaling pathway; cytokine-mediated signaling pathway; type I interferon-mediated signaling pathway; regulation of type I interferon-mediated signaling pathway; ephrin receptor signaling pathway; peptidyl-tyrosine dephosphorylation; axon guidance; T cell costimulation; regulation of cell adhesion mediated by integrin
PTPN6negative regulation of peptidyl-tyrosine phosphorylation; regulation of G1/S transition of mitotic cell cycle; regulation of ERK1 and ERK2 cascade; JAK-STAT cascade involved in growth hormone signaling pathway; regulation of type I interferon-mediated signaling pathway; type I interferon-mediated signaling pathway; regulation of interferon-gamma-mediated signaling pathway; interferon-gamma-mediated signaling pathway; leukocyte migration; peptidyl-tyrosine dephosphorylation; T cell costimulation; cytokine-mediated signaling pathway; protein dephosphorylation; apoptotic process; G-protein coupled receptor signaling pathway; blood coagulation; cell proliferation; positive regulation of cell proliferation; positive regulation of phosphatidylinositol 3-kinase cascade; peptidyl-tyrosine phosphorylation; cell differentiation
RB1interspecies interaction between organisms; myoblast differentiation; positive regulation of macrophage differentiation; negative regulation of S phase of mitotic cell cycle; positive regulation of mitotic metaphase/anaphase transition; negative regulation of smoothened signaling pathway; negative regulation of transcription, DNA-dependent; positive regulation of transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter; digestive tract development; cell morphogenesis involved in neuron differentiation; negative regulation of epithelial cell proliferation; striated muscle cell differentiation; cell division; G1 phase; neuron apoptosis; regulation of cohesin localization to chromatin; negative regulation of transcription involved in G1/S phase of mitotic cell cycle; regulation of centromere complex assembly; protein localization to chromosome, centromeric region; negative regulation of sequence-specific DNA binding transcription factor activity; cell cycle checkpoint; G
RELAnegative regulation of transcription, DNA-dependent; innate immune response; positive regulation of interleukin-12 biosynthetic process; interspecies interaction between organisms; response to amino acid stimulus; positive regulation of I-kappaB kinase/NF-kappaB cascade; negative regulation of apoptotic process; response to hydrogen peroxide; response to drug; negative regulation of protein catabolic process; TRIF-dependent toll-like receptor signaling pathway; toll-like receptor 4 signaling pathway; toll-like receptor 3 signaling pathway; response to morphine; toll-like receptor 2 signaling pathway; positive regulation of transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter; negative regulation of insulin receptor signaling pathway; nerve growth factor receptor signaling pathway; regulation of inflammatory response; T cell receptor signaling pathway; positive regulation of NF-kappaB transcription factor activity; response to cAMP; defense response to virus; nucle
RIPK1positive regulation of extrinsic apoptotic signaling pathway; positive regulation of NF-kappaB transcription factor activity; toll-like receptor 3 signaling pathway; activation of JUN kinase activity; signal transduction; activation of cysteine-type endopeptidase activity involved in apoptotic process; induction of apoptosis; apoptotic process; Toll signaling pathway; induction of apoptosis by extracellular signals; activation of pro-apoptotic gene products; positive regulation of necrotic cell death; positive regulation of interleukin-8 production; MyD88-independent toll-like receptor signaling pathway; positive regulation of tumor necrosis factor production; tumor necrosis factor-mediated signaling pathway; negative regulation of extrinsic apoptotic signaling pathway; toll-like receptor 4 signaling pathway; response to tumor necrosis factor; TRIF-dependent toll-like receptor signaling pathway; positive regulation of programmed cell death; positive regulation of I-kappaB kinase/NF-kappaB cascade; innate immu
RNASEH2ARNA catabolic process; DNA replication
SMARCB1cell differentiation; positive regulation of sequence-specific DNA binding transcription factor activity; positive regulation of transcription from RNA polymerase II promoter; retroviral genome replication; interspecies interaction between organisms; positive regulation by host of viral transcription; DNA integration; nervous system development; negative regulation of cell proliferation; blastocyst hatching; nucleosome disassembly; chromatin remodeling; regulation of transcription from RNA polymerase II promoter; cell cycle
STAT1response to peptide hormone stimulus; endothelial cell migration; response to cAMP; interspecies interaction between organisms; response to exogenous dsRNA; negative regulation of I-kappaB kinase/NF-kappaB cascade; regulation of apoptotic process; response to cytokine stimulus; tumor necrosis factor-mediated signaling pathway; response to lipopolysaccharide; lipopolysaccharide-mediated signaling pathway; cytokine-mediated signaling pathway; negative regulation of angiogenesis; response to bacterium; response to virus; blood circulation; JAK-STAT cascade; induction of apoptosis; regulation of transcription from RNA polymerase II promoter; negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis; positive regulation of mesenchymal cell proliferation; negative regulation of endothelial cell proliferation; negative regulation of transcription from RNA polymerase II promoter; positive regulation of transcription from RNA polymerase II promoter; positive regulation of smooth
STAT3cellular response to hormone stimulus; response to organic cyclic compound; cytokine-mediated signaling pathway; sexual reproduction; intracellular receptor mediated signaling pathway; response to estradiol stimulus; cell proliferation; negative regulation of transcription from RNA polymerase II promoter; temperature homeostasis; eye photoreceptor cell differentiation; regulation of transcription, DNA-dependent; regulation of transcription from RNA polymerase II promoter; protein import into nucleus; cellular component movement; acute-phase response; signal transduction; JAK-STAT cascade; nervous system development; response to cytokine stimulus; regulation of multicellular organism growth; interleukin-6-mediated signaling pathway; nerve growth factor receptor signaling pathway; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; positive regulation of Notch signaling pathway; response to ethanol; interspecies interaction between organisms
STAT5Aresponse to peptide hormone stimulus; allantoin metabolic process; luteinization; citrate metabolic process; 2-oxoglutarate metabolic process; succinate metabolic process; oxaloacetate metabolic process; positive regulation of multicellular organism growth; regulation of cell adhesion; regulation of epithelial cell differentiation; response to nutrient levels; positive regulation of natural killer cell differentiation; negative regulation of mast cell apoptosis; JAK-STAT cascade; T cell differentiation in thymus; regulation of multicellular organism growth; regulation of transcription from RNA polymerase II promoter; positive regulation of activated T cell proliferation; T cell homeostasis; negative regulation of apoptotic process; positive regulation of B cell differentiation; fatty acid metabolic process; creatine metabolic process; valine metabolic process; isoleucine metabolic process; response to ethanol; female pregnancy; lactation; positive regulation of cell proliferation; peptidyl-tyrosine phosphoryl
STAT6positive regulation of transcription from RNA polymerase II promoter; positive regulation of isotype switching to IgE isotypes; regulation of cell proliferation; response to cytokine stimulus; cytokine-mediated signaling pathway; signal transduction; regulation of transcription from RNA polymerase II promoter; negative regulation of type 2 immune response; negative regulation of transcription from RNA polymerase II promoter
TGFB1I1positive regulation of transforming growth factor beta receptor signaling pathway; ubiquitin-dependent SMAD protein catabolic process; transcription from RNA polymerase II promoter; cell adhesion; negative regulation of cell proliferation; positive regulation of epithelial to mesenchymal transition; Wnt receptor signaling pathway; cell differentiation; positive regulation of transcription, DNA-dependent; negative regulation of transforming growth factor beta receptor signaling pathway; androgen receptor signaling pathway
TP53protein complex assembly; apoptotic process; regulation of transcription, DNA-dependent; double-strand break repair; nucleotide-excision repair; base-excision repair; T cell lineage commitment; B cell lineage commitment; T cell proliferation involved in immune response; somitogenesis; in utero embryonic development; DNA strand renaturation; negative regulation of transcription from RNA polymerase II promoter; cell cycle checkpoint; protein import into nucleus, translocation; positive regulation of neuron apoptosis; positive regulation of peptidyl-tyrosine phosphorylation; negative regulation of fibroblast proliferation; regulation of mitochondrial membrane permeability; response to antibiotic; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; negative regulation of transcription, DNA-dependent; interspecies interaction between organisms; regulation of catalytic activity; negative regulation of apoptotic process; positive regulation of ap
TRADDsignal transduction; induction of apoptosis; induction of apoptosis by extracellular signals; activation of pro-apoptotic gene products; tumor necrosis factor-mediated signaling pathway; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of hair follicle development; extrinsic apoptotic signaling pathway; activation of cysteine-type endopeptidase activity involved in apoptotic process; apoptotic process
TUBB2Aprotein polymerization; 'de novo' posttranslational protein folding; cellular protein metabolic process; neuron differentiation; mitosis; microtubule-based movement; protein folding
TYRmelanin biosynthetic process from tyrosine; eye pigment biosynthetic process; visual perception; cell proliferation; pigmentation; thymus development
VASPT cell receptor signaling pathway; neural tube closure; axon guidance; actin polymerization or depolymerization; actin cytoskeleton organization; protein homotetramerization; cell junction assembly
VIL1regulation of lamellipodium morphogenesis; cellular response to epidermal growth factor stimulus; regulation of wound healing; cytoplasmic actin-based contraction involved in cell motility; protein complex assembly; epidermal growth factor receptor signaling pathway; regulation of cell shape; response to bacterium; positive regulation of epithelial cell migration; negative regulation of endopeptidase activity; actin filament polymerization; actin filament depolymerization; positive regulation of cell migration; cytoskeleton organization; actin filament capping; positive regulation of actin filament bundle assembly; cellular response to hepatocyte growth factor stimulus; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; actin filament severing; regulation of actin nucleation
XRCC6double-strand break repair; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; negative regulation of transcription, DNA-dependent; V(D)J recombination; initiation of viral infection; provirus integration; viral reproduction; response to ionizing radiation; double-strand break repair via nonhomologous end joining; DNA ligation; positive regulation of neurogenesis; telomere maintenance; DNA repair
YWHAGprotein targeting; regulation of signal transduction; negative regulation of protein kinase activity; G2/M transition of mitotic cell cycle; mitotic cell cycle; regulation of synaptic plasticity; regulation of neuron differentiation