Molecular Targets in Cancer Drug Discovery: Cell-Based Profiling
Curr Pharm Des 2000 Mar;6(4):473-83
The phrase "molecular target-based drug discovery" usually implies an in vitro biochemical
assay or battery of assays. One portion of the U.S. National Cancer Institute's drug discovery
program, to the contrary, examines molecular targets for cancer therapy in a cell-based format.
That approach has a number of significant limitations, but it has produced databases of
significant utility on the activities and structures of tested compounds, as well as on
molecular characteristics of the cell types used for testing.