A Postgenomic Visual Icon.
An information-intensive approach to the molecular pharmacology of cancer.
Biomarkers in Cancer Staging, Prognosis and Treatment Selection
The p53 Tumor Suppressor Network Is a Key Responder to Microenvironmental Components
of Chronic Inflammatory Stress
Molecular Interaction Maps of Bioregulatory Networks:
A General Rubric for Systems Biology
Nova regulates brain-specific splicing to shape the synapse
High-Throughput GoMiner, an 'industrial-strength' integrative Gene Ontology tool for
interpretation of multiple-microarray experiments, with application to studies of
Common Variable Immune Deficiency (CVID)
Quality assessment of microarrays: Visualization of spatial artifacts and quantitation of regional biases
Workshop on Cancer Biometrics: Identifying Biomarkers and Surrogates of Cancer
in Patients: A Meeting Held at the Masur Auditorium, National Institutes of Health.
Karyotypic "state" as a potential determinant for anticancer drug discovery
Predicting Drug Sensitivity and Resistance: Profiling ABC Transporter Genes in Cancer Cells
Membrane Transporters and Channels: Role of the Transportome in Cancer
Chemosensitivity and Chemoresistance
Mistaken Identifiers: Gene name errors can be introduced inadvertently when
using Excel in bioinformatics
Properties of Switch-like Bioregulatory Networks Studied by Simulation of the
Hypoxia Response Control System
Molecular Interaction Maps--A Diagrammatic Graphical Language for Bioregulatory Networks
Cancer Drug Discovery: Genomics, Proteomics, and Bioinformatics
Linking Drugs and Genes: Pharmacogenomics, Pharmacoproteomics,
Bioinformatics, and the NCI-60.
Karyotypic complexity of the NCI-60 drug-screening panel
Proteomic Profiling of the NCI-60 Cancer Cell Lines Using New High-density
Reverse-phase Lysate Microarrays
Diagnostic Markers That Distinguish Colon and Ovarian Adenocarcinomas:
Identification by Genomic, Proteomic, and Tissue Array Profiling
Impact of p53-knockout and Topotecan Treatment on Gene Expression Profiles in Human Colon
Carcinoma Cells: A Pharmacogenomics Study.
MatchMiner: A Tool for Batch Navigation among
Gene and Gene Product Identifiers
GoMiner: A Resource for Biological Interpretation
of Genomic and Proteomic Data
Pharmacogenomic Analysis: Correlating Molecular Substructure Classes with Microarray Gene Expression Data
Transcriptional Regulation of Mitotic Genes by Camptothecin-Induced DNA Damage:
Microarray Analysis of Dose- and Time-Dependent Effects
The Bioinformatics of Microarray Gene Expression Profiling
'Omic' and Hypothesis-driven Research in the Molecular Pharmacology of Cancer
Chemosensitivity Prediction by Transcriptional Profiling.
The DNA-repair Gene MGMT and the Clinical Response of Gliomas to Alkylating Agents
Quantitative Structure-Antitumor Activity Relationships
of Camptothecin Analogues: Cluster Analysis and Genetic Algorithm-Based Studies
Comparison of a Neural
Net-based QSAR Algorithm (PCANN) with Hologram- and Multiple Linear Regression-based
QSAR Approaches: Application to 1,4-dihydropyridine-based Calcium Channel Antagonists
Searching for Pharmacogenomic Markers:
the Synergy Between Omic and Hypothesis-Driven Research
A Gene Expression Database for the Molecular Pharmacology of Cancer
Systematic Variation in Gene Expression Patterns in Human Cancer Cell Lines
EDGAR: Extraction of Drugs, Genes and Relations from the Biomedical Literature
Mining and Visualizing Large Anticancer Drug Discovery Databases
Pharmacogenomics: Teaching Old Drugs New Tricks
Combination Gene Therapy: Synergistic Inhibition of Human Immunodeficiency Virus Tat
and Rev Functions by a Single RNA Molecule
Molecular Targets in Cancer Drug Discovery: Cell-Based Profiling
MedMiner: An internet tool for filtering and organizing biomedical information, with application
to gene expression profiling.
The Complexity of Radiation Stress Responses: Analysis by Informatics and
Functional Genomics Approaches
Gadd45, a p53-Responsive Stress Protein, Modifies DNA Accessibility on Damaged
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This web site is a development of the Genomics and Pharmacology Facility, Developmental Therapeutics Branch (DTB), Center for Cancer Research (CCR), National Cancer Institute (NCI).