Selected Articles from the Genomics and Bioinformatics Group: Pre-1999 (followed by full bibliography)
Weinstein, J.N., Myers, T.G., O'Connor, P.M., Friend, S.H., Fornace,
A.J., Kohn, K.W., Fojo, T., Bates, S.E., Rubinstein, L.V., Anderson, N.L., Buolamwini,
J.K., van Osdol, W.W., Monks, A.P., Scudiero, D.A., Sausville, E.A., Zaharevitz, D.W.,
Bunow, B., Viswanadhan, V.N., Johnson, G.S., Wittes, R.E., and Paull, K.D. An
information-intensive approach to the molecular pharmacology of cancer. Science 1997; 275:343-349.
Abstract Full Text (PDF) Weinstein, J.N., Fishing expeditions, Science 1998; 282: 627-628 ( in Genome issue).
Abstract Shi, L.M., Fan, Y., Myers, T.G., and Weinstein, J.N. Genetic
function approximation in the molecular pharmacology of cancer. Symp. Intl Congress on
Neural Networks, 1997; 1.
Li, G., Waltham, M., Unsworth, E., Treston, A., Anderson, N.L., and
Weinstein, J.N. Rapid protein identification from two-dimensional polyacrylamide gels
by MALDI mass spectrometry. Electrophoresis 1997; 18:391-402..
Myers, T.G., Waltham, M., Li, G., Buolamwini, J.K., Scudiero, D.A.,
Rubinstein, L.V., Paull, K.D., Sausville, E.A., and Anderson, N.L., and Weinstein, J.N.
A protein expression database for the molecular pharmacology of cancer.
Electrophoresis 1997; 18:647-653.
O'Connor, P.M., Jackman, J., Bae, I., Myers, T.G., Fan, S., Scudiero,
D.A., Monks, A., Sausville, E.A., Weinstein, J.N., Friend, S., Fornace, A.J., Jr., and
Kohn, K.W. Characterization of the p53 tumor suppressor pathway in the NCI anticancer
drug screen cell lines and relationships with chemosensitivity, Cancer Research, 1997;
57: 4285-4300. Abstract
Full Text (PDF)
Burke, H.B., Goodman, P.H., Rosen, D.B., Weinstein, J.N., Hellier,
J.H., Winchester, D.P., Harrell, F.E., Marks, J.R., Bostwick, D.G., Osteen, R.T., Zincke,
H., and Henson, D.E. Improving cancer survival prediction accuracy. Cancer 1997;
79: 857-862.
Wosikowski, K., Schuurhuis, D., Johnson, K., Paull, K.D., Myers,
T.G., Weinstein, J., and Bates, S.E. Use of EGF receptor, c-erbB2 and TGF a gene
expression profiles in the National Cancer Institute anticancer drug screen to identify
EGF receptor and c-erbB2 pathway inhibitors. J. Natl. Cancer Inst., 1997; 89:
1505-1515.
Weinstein, J.N., Myers, T.G., O'Connor, P.M., Friend, S.H., Fornace,
A.J., Kohn, K.W., Fojo, T., Bates, S.E., Rubinstein, L.V., Anderson, N.L., Buolamwini,
J.K., van Osdol, W.W., Monks, A.P., Scudiero, D.A., Sausville, E.A., Zaharevitz, D.W.,
Bunow, B., Viswanadhan, V.N., Johnson, G.S., Wittes, R.E., and Paull, K.D. An
information-intensive approach to the molecular pharmacology of cancer. Science 1997;
275:343-349.
Shi, L.M., Fan, Y., Myers, T.G., Waltham, M., Paull, K.D., and
Weinstein, J.N. Mining the anticancer activity database generated by the U.S. National
Cancer Institute's drug discovery program using statistical and artificial intelligence
techniques, Mathematical Modeling and Scientific Computing 1998; 38:189-199.
Shi, L.M., Myers, T.G., Fan, Y., O'Connor, P.M., Paull, K.D.,
Friend, S.H., and Weinstein, J.N. Mining the NCI anticancer drug discovery
database: Cluster analysis of ellipticine analogs with p53-inverse and central nervous
system-selective patterns of activity. Molecular Pharmacology 1998; 53: 241-251.
Shi, L.M., Fan, Y., Myers, T.G., Paull, K.D., and Weinstein, J.N.
Mining the NCI anticancer drug discovery databases: Genetic function approximation for the
quantitative structure-activity relationship study of anticancer ellipticine analogs.
J. Chem. Inf. Comput. Sci. 1998; 38: 189-199.
Fan, Y., Weinstein, J.N., Kohn, K.W., Shi, L.M., and Pommier, Y. Molecular
modeling studies of the DNA - topoisomerase I ternary cleavable complex with camptothecin.
J. Med. Chem. 1998; 41: 2216-2226.
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