Rxn file:  rf.A5a  --  Fig 7B

.A5- adds feedbk fr E2F to cyE synth.
.A5a- vary x16 .1,.2,.4,...,128 (8x3)

dt   nsteps%  nsubsteps%
  i   i1  i2  i3  o1  o2  o3  e   k
i   x0  endptConc  x$
*
1, 320,100 
  1, 17,  0,  0,  1,  0,  0,  0, 0, +
  2,  1,  0,  0, 19,  0,  0,  0, 0, +
  3,  1,  2,  0,  3,  0,  0,  0, 0, +
  4,  3,  0,  0,  1,  2,  0,  0, 0, +
  5,  3, 10,  0,  6,  0,  0,  0, 0, +
  6,  6,  0,  0,  3, 10,  0,  0, 0, +
  7,  6,  0,  0,  3,  5,  7,  0, 0, +
  8,  4,  5,  0, 10,  0,  0,  0, 1, k 1
  9, 10,  0,  0,  4,  5,  0,  0, 0, k_
 10,-18,  0,  0,  4,  0,  0,  0, 0, s
 11,  4,  0,  0, 19,  0,  0,  0, 0, d
 12, 12,  0,  0, 19,  0,  0,  0, 0, d2
 13, 11, 12,  0, 13,  0,  0,  0, 1, k1
 14, 13,  0,  0, 11, 12,  0,  0, 1, k_1
 15, 10, 13,  0, 14,  0,  0,  0, .1, b  .1
 16, 14,  0,  0, 10, 13,  0,  0, 10, + 10
 17, 14,  0,  0,  5,  7, 13,  0, 1, + 1
 18,-20,  0,  0,  5,  0,  0,  0, 1, s1
 19,  5, 22,  0, 23,  0,  0,  0, 2, d1
 20, 23,  0,  0, 22,  0,  0,  0, 2, d1/Df
 21,  5, 16,  0, 21,  0,  0,  0, 1, + 1
 22, 21,  0,  0,  5, 16,  0,  0, 1, + 1
 23,-21,  0,  0, 24,  0,  0,  0, 1, c 8
 24,-21,  0,  0,  5,  0,  0,  0, 0, +
 25,  5,  0,  0, 19,  0,  0,  0, .1, +
 26,-24,  0,  0, 12,  0,  0,  0, 1, +
 27, 13,  0,  0, 11, 25,  0,  0, 1, +
 28, 24,  0,  0, 19,  0,  0,  0, .1, +
 29,  4, 13,  0,  8,  0,  0,-15, 1, =k15
 30,  8,  0,  0,  4, 13,  0,-16, 1, =k16
 31,  8,  0,  0,  7, 13,  0,-17, 1, =k17
 32,  5, 26,  0, 27,  0,  0,  0, 0, + 1
 33, 27,  0,  0,  5, 26,  0,  0, 0, + 1
 34,-27,  0,  0, 28,  0,  0,  0, 0, +
 35, 28,  0,  0, 19,  0,  0,  0, 0, +
 36,-28,  0,  0,  5,  0,  0,  0, 0, +
 37,-20,  0,  0, 28,  0,  0,  0, 0, +
   0,  0,  0,  0,  0,  0,  0,  0,  0, end
   1, 0   , 0, cyD
   2, 0   , 0, cdk4
   3, 0   , 0, cyD.cdk4
   4, 100   , 0, Rb
  -5, 0   , 0, E2F
   6, 0   , 0, cyD.cdk4.Rb.E2F
   7, 0   , 0, RbP
   8, 0   , 0, cyE.cdk2.Rb
   9, 0   , 0, not used
  10, 0   , 0, Rb.E2F
  11, 16   , 0, cdk2
  12, 0   , 0, cyE
 -13, 0   , 0, cyE.cdk2
  14, 0   , 0, cyE.cdk2.Rb.E2F
  15, 0   , 0, not used
  16, .2   , 0, E2FelCyEprom
  17, 0   , 0, pre-cyD
  18, 0   , 0, pre-Rb
  19, 0   , 0, degr prod
  20, 1   , 0, unitPrecurs
  21, 0   , 0, E2F.E2FelCyEprom
  22, 1   , 0, protease
  23, 0   , 0, E2F.protease
 -24, 0   , 0, cyEmRNA
  25, 0   , 0, cyE-P
  26, 0   , 0, E2FelE2Fprom
  27, 0   , 0, E2F.E2FelE2Fprom
  28, 0   , 0, E2FmRNA
   0,  0,  0, end
scan2
5
0,16,1,.1,13,2
0,0,0,0,0,0
stop
stop