HTS384 NCI-60 Drug Activity Z Scores
This tool compiles drug activity levels from all HTS384 NCI60 experiments that pass quality control, using the same quality control as the classic NCI60 drug data.
Compounds with no experiments passing quality control are not reported.
The tool provides an Excel spreadsheet for each compound the user has input that includes:
- average compound activity Z scores in a tabular form and visualized as a bar graph (see below).
- all HTS384 NCI60 screening GI50 values (-log10) for those experiments that passed quality control.
- the z-score transforms for each experiment that passed quality control.
The data is queryable using Query Drug Data (http://discover.nci.nih.gov/cellminer/drugQuery.do).
The raw data can be downloaded in total at Download Data Sets page "DTP_HTS384_NCI60_RAW.zip" (http://discover.nci.nih.gov/cellminer/loadDownload.do).
The z-score data can be downloaded in total at Download Data Sets page "DTP_HTS384_NCI60_ZSCORE.zip" (http://discover.nci.nih.gov/cellminer/loadDownload.do).
A brief platform description is available in Data Set Metadata page under "Drug: Compound activity: DTP HTS384 NCI-60" (http://discover.nci.nih.gov/cellminer/datasets.do).
Raw luminescence values are normalized against vehicle controls, adjusted for background, and used to generate dose-response curves and calculate key endpoints GI50.
[PMID:38861359] HTS384 NCI60: The Next Phase of the NCI60 Screen
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Table 1: Average Compound Activity Z Scores |
|
| BR:MCF7 |
0.731 |
| BR:MDA_MB_231 |
-4.400 |
| BR:HS578T |
-0.570 |
| BR:BT_549 |
0.731 |
| BR:T47D |
- |
| CNS:SF_268 |
0.731 |
| CNS:SF_295 |
-0.208 |
| CNS:SF_539 |
0.731 |
| CNS:SNB_19 |
-1.401 |
| CNS:SNB_75 |
0.064 |
| CNS:U251 |
-1.075 |
| CO:COLO205 |
- |
| CO:HCC_2998 |
-0.243 |
| CO:HCT_116 |
0.731 |
| CO:HCT_15 |
0.731 |
| CO:HT29 |
0.731 |
| CO:KM12 |
0.731 |
| CO:SW_620 |
0.731 |
| LE:CCRF_CEM |
0.731 |
| LE:HL_60 |
0.731 |
| LE:K_562 |
0.731 |
| LE:MOLT_4 |
0.731 |
| LE:RPMI_8226 |
-0.425 |
| LE:SR |
- |
| ME:LOXIMVI |
0.731 |
| ME:MALME_3M |
-0.606 |
| ME:M14 |
0.731 |
| ME:SK_MEL_2 |
- |
| ME:SK_MEL_28 |
-0.967 |
| ME:SK_MEL_5 |
- |
| ME:UACC_257 |
- |
| ME:UACC_62 |
-0.461 |
| ME:MDA_MB_435 |
0.731 |
| ME:MDA_N |
- |
| LC:A549 |
0.731 |
| LC:EKVX |
0.731 |
| LC:HOP_62 |
-1.328 |
| LC:HOP_92 |
- |
| LC:NCI_H226 |
-0.642 |
| LC:NCI_H23 |
-0.967 |
| LC:NCI_H322M |
0.009 |
| LC:NCI_H460 |
- |
| LC:NCI_H522 |
-0.714 |
| OV:IGROV1 |
-1.003 |
| OV:OVCAR_3 |
-0.497 |
| OV:OVCAR_4 |
0.731 |
| OV:OVCAR_5 |
0.731 |
| OV:OVCAR_8 |
0.731 |
| OV:SK_OV_3 |
-1.654 |
| OV:NCI_ADR_RES |
0.731 |
| PR:PC_3 |
0.731 |
| PR:DU_145 |
0.731 |
| RE:786_0 |
0.731 |
| RE:A498 |
0.731 |
| RE:ACHN |
-1.003 |
| RE:CAKI_1 |
-0.786 |
| RE:RXF_393 |
0.731 |
| RE:SN12C |
0.731 |
| RE:TK_10 |
-0.497 |
| RE:UO_31 |
-0.967 |
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NSC 740 Average Compound Activity Z Scores
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