HTS384 NCI-60 Drug Activity Z Scores

The tool provides an Excel spreadsheet for each compound the user has input that includes:

  1. Compound activity Z scores in a tabular form and visualized as a bar graph (see below).
  2. HTS384 NCI60 screening GI50 values for the experiment.

The data is queryable using Query Drug Data (http://discover.nci.nih.gov/cellminer/drugQuery.do).
The raw data can be downloaded in total at Download Data Sets page "DTP_HTS384_NCI60_RAW.zip" (http://discover.nci.nih.gov/cellminer/loadDownload.do).
The z-score data can be downloaded in total at Download Data Sets page "DTP_HTS384_NCI60_ZSCORE.zip" (http://discover.nci.nih.gov/cellminer/loadDownload.do).
A brief platform description is available in Data Set Metadata page under "Drug: Compound activity: DTP HTS384 NCI-60" (http://discover.nci.nih.gov/cellminer/datasets.do).
Raw luminescence values are normalized against vehicle controls, adjusted for background, and used to generate dose-response curves and calculate key endpoints GI50.
[PMID:38861359] HTS384 NCI60: The Next Phase of the NCI60 Screen


Table 1: Compound Activity Z Scores

Cell lines Z scores

BR:MCF7 0.739
BR:MDA_MB_231 -4.444
BR:HS578T -0.575
BR:BT_549 0.739
BR:T47D -
CNS:SF_268 0.739
CNS:SF_295 -0.21
CNS:SF_539 0.739
CNS:SNB_19 -1.415
CNS:SNB_75 0.064
CNS:U251 -1.086
CO:COLO205 -
CO:HCC_2998 -0.247
CO:HCT_116 0.739
CO:HCT_15 0.739
CO:HT29 0.739
CO:KM12 0.739
CO:SW_620 0.739
LE:CCRF_CEM 0.739
LE:HL_60 0.739
LE:K_562 0.739
LE:MOLT_4 0.739
LE:RPMI_8226 -0.429
LE:SR -
ME:LOXIMVI 0.739
ME:MALME_3M -0.612
ME:M14 0.739
ME:SK_MEL_2 -
ME:SK_MEL_28 -0.977
ME:SK_MEL_5 -
ME:UACC_257 -
ME:UACC_62 -0.466
ME:MDA_MB_435 0.739
ME:MDA_N -
LC:A549 0.739
LC:EKVX 0.739
LC:HOP_62 -1.342
LC:HOP_92 -
LC:NCI_H226 -0.648
LC:NCI_H23 -0.977
LC:NCI_H322M 0.009
LC:NCI_H460 -
LC:NCI_H522 -0.721
OV:IGROV1 -1.031
OV:OVCAR_3 -0.502
OV:OVCAR_4 0.739
OV:OVCAR_5 0.739
OV:OVCAR_8 0.739
OV:SK_OV_3 -1.67
OV:NCI_ADR_RES 0.739
PR:PC_3 0.739
PR:DU_145 0.739
RE:786_0 0.739
RE:A498 0.739
RE:ACHN -1.013
RE:CAKI_1 -0.794
RE:RXF_393 0.739
RE:SN12C 0.739
RE:TK_10 -0.502
RE:UO_31 -0.977

 
 
     

NSC 740 Compound Activity Z Scores

This is a bar chart of the nci60 cell lines with the HTS384 Drug activity z-score values (a visual representation of the data contained in table 1).