MIM Home

Home

Publications

Tools

Data Sets

μA Analysis

Members

Links

Contact

A Molecular Interaction Map (MIM) is a diagram convention that is capable of unambiguous representation of networks containing multi-protein complexes, protein modifications, and enzymes that are substrates of other enzymes. This graphical representation makes it possible to view all of the many interactions in which a given molecule may be involved, and it can portray competing interactions, which are common in bioregulatory networks. In order to facilitate linkage to databases, each molecular species is represented only once in a diagram. Molecular species can be located on the map by means of indexed grid coordinates and on eMIMs through interactive links. Each interaction is referenced to an annotation list where pertinent information and references can be found.

How to read maps

eMIMs (interactive)

Kohn Interaction Maps (static)

Interactive electronic molecular interaction maps (eMIMs) allow the user to navigate through the molecular interaction network and link to molecular databases, references and annotations that contain pertinent information.

Molecular interaction maps (MIMs) describing the mammalian cell cycle and DNA repair control network. These maps show how multi-protein complexes could assemble and function at gene promoter sites and at sites of DNA damage. It also portrays the richness of connections between the p53-Mdm2 subsystem and other parts of the network.

Featured eMIMs:

• Histone	chromatin assembly during replication.
• Replication	cell cycle regulation of the early stages of DNA synthesis.
• Hypoxia	transcriptional activation in response to low oxygen levels.
• Chk2	cellular response to DNA double-strand breaks (DSB).
• p53 and Mdm2	regulatory response to DNA damage.
• EGFR	heuristic MIM of signaling from EGF receptors.

• Map A: Cyclins & E2F

• Map B: p53 & DNA repair

References

Annotation List

Molecular Species Index

Abbreviations

RNfb program files

An animated description of the steps leading to src activation by EGFR is available (powerpoint).