SIRT1/PARP1 crosstalk: connecting DNA damage and metabolism
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Augustin Luna, Mirit I. Aladjem and Kurt W Kohn
Implemented by : Margot Sunshine
An intricate network regulates the activities of SIRT1 and PARP1 proteins and continues to be uncovered.
Both SIRT1 and PARP1 share a common co-factor nicotinamide adenine dinucleotide (NAD+) and several common substrates,
including regulators of DNA damage response and circadian rhythms.
We review this complex network using an interactive Molecular Interaction Map (MIM) to explore the interplay between these two proteins.
Here we discuss how NAD + competition and post-transcriptional/translational feedback mechanisms create a regulatory
network sensitive to environmental cues, such as genotoxic stress and metabolic states, and examine the role of those
interactions in DNA repair and ultimately, cell fate decisions.
Link to paper
