A Molecular Interaction Map (MIM) is a diagram convention that is capable of unambiguous representation of networks containing multi-protein complexes, protein modifications, and enzymes that are substrates of other enzymes. This graphical representation makes it possible to view all of the many interactions in which a given molecule may be involved, and it can portray competing interactions, which are common in bioregulatory networks. In order to facilitate linkage to databases, each molecular species is represented only once in a diagram. A formal description of the MIM notation can be found in Kohn et al., Molecular Biology of the cell 17, 1-13 2006. The updated formal specification for software implementation can be found in Luna et al., BMC Bioinformatics 2011, 12:167.

For a quick reference sheet of the MIM symbols click here.

Current diagram editors implementing these symbols are Pathvisio and MIMTool.

MIM Diagrams: Interactive electronic molecular interaction maps (eMIMs) allow the user to navigate through the molecular interaction network and link to molecular databases, references and annotations that contain pertinent information.

Molecular species can be located on the map by means of indexed grid coordinates and on eMIMs through interactive links. Each interaction is referenced to an annotation list where pertinent information and references can be found.

MIM Software: There are several ongoing software projects to simplify creating and editing MIM diagrams and related metadata. Some of the software components provided allow developers to speed up the development of MIM support, allow for interoperable tools, and to provide a means of mining the data contained in MIM diagrams for other uses.

eMIMs (interactive):

Older maps may use variant sets of symbols as described in the publications associated with each map.
Electronic Molecular Interaction Map of a replication block

Kohn Interaction Maps (static)

MIM Software:

Systems Biology Graphical Notation

The MIM notation was the basis for the development of the entity-relationship component (SBGN-ER) of the Systems Biology Graphical Notations (SBGN). SBGN is an international effort to standardize diagrams depicting biochemical and cellular processes studied in systems biology, including several notations designed for different purposes.

An animated description of the steps leading to src activation by EGFR is available (pdf).

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