Regulation of hypoxia-responsive genes
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Kurt W. Kohn, Joseph Riss, Mirit Aladjem and Yves Pommier
Implemented by : Margot Sunshine, Hong Cao and David KaneTo read the original paper describing this map and the symbols used, click here.
This molecular interaction map depicts the regulatory network that inhibits transcription in the presence of normal oxygen levels and switches HIF-mediated transcription on when oxygen levels are reduced. An analysis of the hypoxia-induced regulatory switch can be accessed here
This web site is a development of the Genomics and Pharmacology Facility, Developmental Therapeutics Branch (DTB), Center for Cancer Research (CCR), National Cancer Institute (NCI).