Molecular interaction map of the p53 and Mdm2 logic elements, which control the Off-On switch of p53 in response to DNA damage
The best way to view the map is with on a PC with Firefox or Chrome and on a MAC with Safari or Chrome.
Date last update: Dec. 21, 2004
Kurt W. Kohn and Yves Pommier
Implemented by : Margot Sunshine, Hong Cao and David KaneTo read the original paper describing this map and the symbols used, click here.
The molecular network that controls responses to genotoxic stress is centered at p53 and Mdm2. Recent findings have shown this network to be more complex than previously envisioned. Using a notation specifically designed for circuit diagram-like representations of bioregulatory networks, we have prepared an updated molecular interaction map of the immediate connections of p53 and Mdm2, which are described as logic elements of the network. We use the map as the basis for a comprehensive review of current concepts of signal processing by these logic elements.
This web site is a development of the Genomics and Pharmacology Facility, Developmental Therapeutics Branch (DTB), Center for Cancer Research (CCR), National Cancer Institute (NCI).