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To lay the foundation of a model, we first assembled the known molecular interactions among p53, Mdm2, and MdmX in the form of a heuristic MIM (Figure 1) using the previously described notation (Kohn, 1999, 2001; Kohn et al., 2006). The heuristic MIM organizes information from which explicit models (Figure 2) for simulations can be extracted and portrayed as an explicit MIM (Kohn 2001).

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