GBG logo Molecular Interaction Maps LMP, CCR, NCI, NIH
Kohn Interaction Maps

MIM home

Kohn Interaction Maps

Symbol Definition Table

Annotation List

References

Molecular Species Index

Abbreviations

RNfb program files

Kohn Molecular Interaction Maps

A diagram convention is described that is capable of unambiguous representation of networks containing multi-protein complexes, protein modifications, and enzymes that are substrates of other enzymes. A map was prepared of the mammalian cell cycle and DNA repair control network. In order to facilitate linkage to a database, each molecular species usually is represented only once in a diagram. Molecular species can be located on the map by means of indexed grid coordinates. Each interaction is referenced to an annotation list where pertinent information and references can be found. Parts of the network are grouped into functional subsystems. The map shows how multi-protein complexes could assemble and function at gene promoter sites and at sites of DNA damage. It also portrays the richness of connections between the p53-Mdm2 subsystem and other parts of the network.

Reference: Kohn, Molec. Biol. Cell 1999 Aug;10(8):2703-34

Suggestions are welcome for further develpment of the map.

Email comments, corrections, or suggestions to kohnk@dc37a.nci.nih.gov or write to Kurt W. Kohn, Laboratory of Molecular Pharmacology, Division of Basic Sciences, NCI, Building 37, Room 5068, NIH, Bethesda, MD 20892.

 


Link to Center for Cancer Research Home Page Link to National Cancer Institute Home Page Link to National Institutes of Health Link to Department of Health & Human Services Home Page