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• Map A: Cyclins & E2F
  

• Map B: p53 & DNA repair
  

Symbol Definition Table

Annotation List

References

Molecular Species Index

Abbreviations

RNfb program files

• Abramova, N. A., Russell, J., Botchan, M., and Li, R. (1997). Interaction between replication protein A and p53 is disrupted after UV damage in a DNA repair-dependent manner. Proc. Natl. Acad. Sci. U S A 94, 7186-7191.
• Avantaggiati, M. L., Ogryzko, V., Gardner, K., Giordano, A., Levine, A. S., and Kelly, K. (1997). Recruitment of p300/CBP in p53-dependent signal pathways. Cell 89, 1175-1184.
• Bai, C., Sen, P., Hofmann, K., Ma, L., Goebl, M., Harper, J. W., and Elledge, S. J. (1996). Skp1 connects cell cycle regulation to the ubiquitin proteolysis machinery through a novel motif, the F-box. Cell 86, 263-274.
• Banin, S., Moyal, L., Shieh, S. Y., Taya, Y., Anderson, C. W., Chessa, L., Smorodinsky, N. I., Prives, C., Reiss, Y., Shiloh, Y., and Ziv, Y. (1998). Enhanced phosphorylation of p53 by ATM in response to DNA damage. Science 281, 1674-1677.
• Baskaran, R., Chiang, G. G., Mysliwiec, T., Kruh, G. D., and Wang, J. Y. J. (1997). Tyrosine phosphorylation of RNA polymerase II carboxyl-terminal domain by the Abl-related gene product. J. Biol. Chem. 272, 18905-18909.
• Baskaran, R., Dahmus, M. E., and Wang, J. Y. J. (1993). Tyrosine phosphorylation of mammalian RNA polymerase II carboxyterminal domain. Proc. Natl. Acad. Sci. U S A 90, 11167-11171.
• Baskaran, R., Wood, L. D., Whitaker, L. L., Canman, C. E., Morgan, S. E., Xu, Y., Barlow, C., Baltimore, D., Wynshaw-Boris, A., Kastan, M. B., and Wang, J. Y. J. (1997). Ataxia telangiectasia mutant protein activates c-Abl tyrosine kinase in response to ionizing radiation. Nature 387, 516-519.
• Bates, S., Phillips, A. C., Clark, P. A., Stott, F., Peters, G., Ludwig, R. L., and Vousden, K. H. (1998). p14ARF links the tumour suppressors RB and p53. Nature 395, 124-125.
• Batsche, E., Muchardt, C., Behrens, J., Hurst, H. C., and Cremisi, C. (1998). RB and c-Myc activate expression of the E-cadherin gene in epithelial cells through interaction with transcription factor AP2. Mol. Cell. Biol. 18, 3647-3658.
• Bauer, P., Farkas, G., Buday, L., Mikala, G., Meszaros, G., Kun, E., and Farago, A. (1992). Inhibition of DNA binding by the phosphorylation of poly ADP-ribose polymerase protein catalysed by protein kinase C. Biochem Biophys Res Commun 187, 730-736.
• Bauman, P., and West, S. C. (1997). The human rad51 protein: Polarity of strand transfer and stimulation by hRPA. EMBO J. 16, 5198-5206.
• Black, A. R., Jensen, D., S-Y., L., and Azizkhan, J. C. (1999). Growth/cell cycle regulation of Sp1 phosphorylation. J. Biol. Chem. 274, 1207-1215.
• Blackwell, L. J., Borowiec, J. A., and Masrangelo, I. A. (1996). Single-stranded-DNA binding alters human replication protein A structure and facilitates interaction with DNA-dependent protein kinase. Mol. Cell. Biol. 16, 4798-4807.
• Blier, P., Griffith, A., Craft, J., and Hardin, J. (1993). Binding of Ku protein to DNA. Measurement of affinity for ends and demonstration of bindng to nicks. J. Biol. Chem. 268, 7594-7610.
• Bochkarev, A., Pfuetzner, R. A., Edwards, A. M., and Frappier, L. (1997). Structure of the single-stranded-DNA-binding domain of replication protein A bound to DNA. Nature 385, 176-181.
• Booher, R. N. j., Holman, P. S., and Fattaey, A. (1997). Human myt1 is a cell cycle-regulated kinase that inhibits cdc2 but not cdk2 activity. J. Biol. Chem. 272, 22300-22306.
• Bottger, A., Bottger, V., Sparks, A., Liu, W. L., Howard, S. F., and P., L. D. (1997). Design of a synthetic Mdm2-binding mini-protein that activates the p53 response in vivo. Curr. Biol. 7, 860-869.
• Braun, K. A., Lao, Y., He, Z., Ingles, C. J., and Wold, M. S. (1997). Role of protein-protein interactions in the function of replication protein A (RPA): RPA modulates the activity of DNA polymerase alpha by multiple mechanisms. Biochemistry 36, 8443-8454.
• Brehm, A., Miska, E. A., McCance, D. J., Reid, J. L., Bannister, A. J., and Kouzarides, T. (1998). Retinoblastoma protein recruits histone deacetylase to repress transcription. Nature 391, 597-601.
• Canman, C. E., Lim, D. S., Cimprich, K., A., Taya, Y., Tamai, K., Sakaguchi, K., Appella, E., Kastan, M. B., and Siliciano, J. D. (1998). Activation of the ATM kinase by ionizing radiation and phosphorylation of p53. Science 281, 1677-1679.
• Cappelli, E., Taylor, R., Cevasco, M., Abbondandolo, A., Caldecott, K., and Frosina, G. (1997). Involvement of XRCC1 and DNA ligase III gene products in DNA base excision repair. J. Biol. Chem. 272, 23970-23975.
• Carrier, F., Georgel, P. T., Pourquier, P., Blake, M., Kontny, H. U., Antinore, M. J., Gariboldi, M., Myers, T. G., Weinstein, J. N., Pommier, Y., and Fornace, A. J. J. (1999). Gadd45, a p53-responsive stress protein, modifies DNA accessibility on damaged chromatin. Mol. Cell. Biol. 19, 1673-1685.
• Cartwright, P., Muller, H., Wagener, C., Holm, K., and Helin, K. (1998). E2F-6: a novel member of the E2F family is an inhibitor of E2F-dependent transcription. Oncogene 17, 611-623.
• Chan, D. W., and Lees-Miller, S. P. (1996). The DNA-dependent protein kinase is inactivated by autophosphorylation of the catalytic subunit. J. Biol. Chem. 271, 8936-8941.
• Chen, C. Y., Oliner, J. D., Zhan, Q., Fornace, A. J., Jr., Vogelstein, B., and Kastan, M. B. (1994). Interactions between p53 and MDM2 in a mammalian cell cycle checkpoint pathway. Proc Natl Acad Sci U S A 91, 2684-8.
• Chen, I. T., Smith, M. L., O'Connor, P. M., and Fornace, A. J., Jr. (1995). Direct interaction of Gadd45 with PCNA and evidence for competitive interaction of Gadd45 and p21Waf1/Cip1 with PCNA. Oncogene 11, 1931-7.
• Chen, J., Silver, D. P., Walpita, D., Cantor, S. B., Gazdar, A. F., Tomlinson, G., Couch, F. J., Weber, B. L., Ashley, T., Livingston, D. M., and Scully, R. (1998). Stable interaction between the products of the BRCA1 and BRCA2 tumor suppressor genes in mitotic and meiotic cells. Mol. Cell 2, 317-328.
• Chen, L., Marechal, V., Moreau, J., Levine, A. J., and Chen, J. (1997). Proteolytic cleavage of the mdm2 oncoprotein during apoptosis. J. Biol. Chem. 272, 22966-73.
• Chen, P. L., Riley, D. J., Chen, Y., and Lee, W.-H. (1996). Retinoblastoma protein positively regulates terminal adipocyte differentiation through direct interaction with C/EBPs. Genes Dev. 10, 2794-2804.
• Chen, P. L., Riley, D. J., Chen-Kiang, S., and Lee, W. H. (1996). Retinoblastoma protein directly interacts with and activates the transcription factor NF-IL6. Proc. Natl. Acad. Sci. USA 93, 465-469.
• Chin, P. L., Momand, J., and Pfeifer, G. P. (1997). In vivo evidence for binding of p53 to consensus binding sites in the p21 and GADD45 genes in response to ionizing radiation. Oncogene 15, 87-99.
• Clurman, B. E., Sheaff, R. J., Thress, K., Groudine, M., and Robers, J. M. (1996). Turnover of cyclin E by the ubiquitin-proteasome pathway is regulated by CDK2 binding and cyclin phosphorylation. Genes Dev. 10, 1979-1990.
• Connelly, C., and Hieter, P. (1996). Budding yeast Skp1 encodes an evolutionarily conserved kinetochore protein required for cell cycle progression. Cell 86, 275-285.
• Dantzer, F., Nasheuer, H.-P., Vonesch, J.-L., de Murcia, G., and Menissier-de-Murcia, J. (1998). Functional association of poly(ADP-ribose) polymerase with DNA polymerase a-primase complex: a link between DNA strand break detection and DNA replication. Nucleic Acids Res. 26, 1891-1898.
• Datta, P. K., Raychaudhuri, P., and Bagchi, S. (1995). Association of p107 with Sp1: Genetically separable regions of p107 are involved in regulation of E2F- and Sp1-dependent transcription. Mol. Cell. Biol. 15, 5444-5452.
• de Laat, W. L., Appeldoorn, E., Sugasawa, K., Weterings, E., Jaspers, N. G. J., and Hoeijmakers, J. H. J. (1998). DNA-binding polarity of human replication protein A positions nucleases in nucleotide excision repair. Genes Dev. 12.
• de Laat, W. L., Siybers, A. M., Odijk, H., Jaspers, N. G. J., and Hoeijmakers, J. H. J. (1998). Mapping of interaction domains between human repair proteins ERCC1 and XPF. Nucleic Acids Res. 26, 4146-4152.
• DeGregori, J., Kowalik, T., and Nevins, J. R. (1995). Cellular targets for activation by the E2F1 transcription factor include DNA synthesis and G1/S-regulatory genes. Mol. Cell. Biol. 15, 4215-4224.
• Desai, D., Wessling, H. C., Fisher, R. P., and Morgan, D. O. (1995). Effects of phosphorylation by CAK on cyclin binding by cdc2 and cdk2. Mol. Cell. Biol. 15, 345-350.
• deVries, E., van Driel, W., Bergsma, W. G., Arnberg, A. C., and van den Vliet, P. C. (1989). HeLa nuclear protein recognizing DNA termini and translocating on DNA forming a regular DNA-multimeric protein complex. J. Mol. Biol. 208, 65-78.
• Diehl, J. A., Zindy, F., and Sherr, C. J. (1997). Inhibition of cyclin D1 phosphorylation on threonine-286 prevents its rapid degradation via the ubiquitin-proteasome pathway. Genes Dev. 11, 957-972.
• Ducommun, B., Brambilla, P., Felix, M., Franza, B. R., Karsenti, E., and Draetta, G. (1991). Cdc2 phosphorylation is required for its interaction with cyclin. EMBO J. 10, 3311-3319.
• Dutta, A., Ruppert, J. M., Aster, J. C., and Winchester, E. (1993). Inhibition of DNA replication factor RPA by p53. Nature 365, 79-82.
• Dutta, A., and Stillman, B. (1992). cdc2 family kinases phosphorylate a human cell DNA replication factor, RPA, and activate DNA replication. EMBO J. 11, 2189-2199.
• Duyster, J., Baskaran, R., and Wang, J. Y. J. (1995). Src homology 2 domain as a specificity determinant in the c-Abl-mediated tyrosine phosphorylation of the RNA polymerase II carboxyl-terminal repeated domain. Proc. Natl. Acad. Sci. U S A 92, 1555-1559.
• Dynlacht, B. D., Moberg, K., Lees, J. A., Harlow, E., and Zhu, L. (1997). Specific regulation of E2F family members by cyclin-dependent kinases. Mol. Cell. Biol. 17, 3867-3875.
• Dyson, N. (1998). The regulation of E2F by pRB-family proteins (Review). Genes Dev. 12, 2245-2262.
• el-Deiry, W. S. (1998). Regulation of p53 downstream genes. Semin. Cancer Biol. 8, 345-357.
• Elkeles, A., Juven-Gershon, T., Israeli, D., Wilder, S., Zalcenstein, A., and Oren, M. (1999). The c-fos proto-oncogene is a target for transactivation by the p53 tumor suppressor. Mol. Cell. Biol. 19, 2594-2600.
• Erhardt, P., Tomaselli, K. J., and Cooper, G. M. (1997). Identification of the MDM2 oncoprotein as a substrate for CPP32-like apoptotic proteases. J. Biol. Chem. 272, 15049-15052.
• Evans, E., Fellows, J., Coffer, A., and Wood, R. D. (1997). Open complex formation around a lesion during nucleotide excision repair provides a structure for cleavage by human XPG protein. EMBO J. 16, 625-638.
• Evans, E., Moggs, J. G., Hwang, J., Egly, J., and Wood, R. D. (1997). Mechanism of open complex and dual incision formation by human nucleotide excision repair factors. EMBO J. 16, 6559-6573.
• Ferreira, R., Magnaghi-Jaulin, L., Robin, P., Harel-Bellan, A., and Trouche, D. (1998). The three members of the pocket proteins family share the ability to repress E2F activity through recruitment of a histone deacetylase. Proc. Natl. Acad. Sci. U S A 95, 10493-10498.
• Fisher, R. P., and Morgan, D. O. (1994). A novel cyclin associates with MO15/cdk7 to form the cdk-activating kinase. Cell 78, 713-724.
• Freedman, D. A., and Levine, A. J. (1998). Nuclear export is required for degradation of endogenous p53 by MDM2 and human papillomavirus E6. Mol. Cell. Biol. 18, 7288-7293.
• Freedman, D. A., and Levine, A. J. (1999). Regulation of the p53 protein by the MDM2 oncoprotein -- Thirty-eighth G. H. A. Clowes Memorial Award Lecture. Cancer Res. 59, 1-7.
• Fuchs, S. Y., Adler, V., Buschmann, T., Wu, X., and Ronai, Z. (1998). Mdm2 association with p53 targets its ubiquitination. Oncogene 17, 2543-2547.
• Gabrielli, B. G., Clark, J. M., McCormack, A. K., and Ellem, K. A. O. (1997). Hyperphosphorylation of the N-terminal domain of Cdc25 regulates activity toward Cyclin B1/Cdc2 but not Cyclin A/Cdk2. J. Biol. Chem. 272, 28607-28614.
• Galaktionov, K., Chen, X., and Beach, D. (1996). Cdc25 cell-cycle phosphatase as a target of c-myc. Nature 382, 511-517.
• Galaktionov, K., Jessus, C., and Beach, D. (1995). Raf-1 interaction with Cdc25 phosphatase ties mitogenic signal transduction to cell cycle activation. Genes Dev. 9, 1046-1058.
• Gary, R., Ludwig, D. L., Cornelius, H. L., MacInnes, M. A., and Park, M. S. (1997). The DNA repair endonuclease XPG binds to proliferating cell nuclear antigen (PCNA) and shares sequence elements with the PCNA-binding regions of FEN-1 and cyclin-dependent kinase inhibitor p21. J. Biol. Chem. 272, 24522-24529.
• Gately, D. P., Hittle, J. C., Chan, C. K. T., and Yen, T. J. (1998). Characterization of ATM expression, localization, and associated DNA-dependent protein kinase activity. Molec. Biol. Cell 9, 2361-2374.
• Gaubatz, S., Imhof, A., Dosch, R., Werner, O., Mitchell, P., Buettner, R., and Eilers, M. (1995). Transcriptional activation by Myc is under negative control by the transcriptional factor AP-2. EMBO J. 14, 1508-1519.
• Gaubatz, S., Wood, J. G., and Livingston, D. M. (1998). Unusual proliferation arrest and transcriptional control properties of a newly discovered E2F family member, E2F-6. Proc. Natl. Acad. Sci. U S A 95, 9190-9195.
• Gibbs, E., Kelman, Z., Gulbis, J. M., O'Donnell, M., Kuriyan, J., Burgers, P. M. J., and Hurwitz, J. (1997). The influence of the proliferating cell nuclear antigen-interacting domain of p21(CIP1) on DNA synthesis catalyzed by the human and Saccharomyces cerevisiae polymerase delta holoenzymes. J. Biol. Chem. 272, 2373-2381.
• Gibbs, E., Pan, Z.-Q., Niu, H., and Hurwitz, J. (1996). Studies on the in vitro phosphorylation of HSSB-p34 and -p107 by cyclin-dependent kinases: Cyclin-substrate interactions dictate the efficiency of phosphorylation. J. Biol. Chem 271, 22847-22854.
• Glover, D. M., Hagan, I. M., and Tavares, A. A. M. (1998). Polo-like kinases: a team that plays throughout mitosis. Genes Dev. 12, 1377-3787.
• Golub, E. I., Gupta, R., Haaf, T., Wold, M. S., and Radding, C. M. (1998). Interaction of human Rad51 recombintion protein with single-stranded DNA binding protein, RPA. Nucleic Acids Res. 26, 5388-5393.
• Gomes, X. V., Henricksen, L. A., and Wold, M. S. (1996). Proteolytic mapping of human replication protein A: evidence for multiple structural domains and a conformational change upon interaction with single-stranded DNA. Biochemistry 35, 5586-5595.
• Gotoh, A., and Broxmeyer, H. E. (1997). The function of BCR/ABL and related proto-oncogenes. Curr. Opin. Hematol. 4, 3-11.
• Grossman, S. R., Perez, M., Kung, A. L., Joseph, M., Mansur, C., Xiao, Z.-X., Kumar, S., Howley, P. M., and Livingston, D. M. (1998). p300/MDM2 complexes participate in MDM2-mediated p53 degradation. Molecular Cell 2, 405-415.
• Gu, W., and Roeder, R. G. (1997). Activation of p53 sequence-specific DNA binding by acetylation of the p53 C-terminal domain. Cell 90, 595-606.
• Hamanaka, R., Maloid, S., Smith, M. R., O'Connell, C. D., Longo, D. L., and Ferris, D. K. (1994). Cloning and characterization of human and murine homologues of the Drosopnila polo serine-threonine kinase. Cell Growth Differ. 5, 249-257.
• Hang, H., Chou, H. S., and Zhu, L. (1998). Requirement of cyclin E-cdk2 inhibition in p16ink4a-mediated growth suppression. Mol. Cell. Biol. 18, 5284-5290.
• Hao, M., Lowy, A. M., Kapoor, M., Deffie, A., Liu, G., and Lozano, G. (1997). Mutation of phosphoserine 389 affects p53 function in vivo. J. Biol. Chem. 271, 29380-29385.
• Hateboer, G., Kerkhoven, R. M., Shvarts, A., Bernards, R., and Beijersbergen, R. L. (1996). Degradation of E2F by the ubiquitin-proteasome pathway: regulation by retinoblastoma family proteins and adenovirus transforming proteins. Genes Dev. 10, 2960-2970.
• Haupt, Y., Maya, R., Kazaz, A., and Oren, M. (1997). Mdm2 promotes the rapid degradation of p53. Nature 387, 296-9.
• He, Z., Henricksen, L. A., Wold, M. S., and Ingles, C. J. (1995). RPA involvement in the damage-recognition and incision steps of nucleotide excision repair. Nature 374, 566-569.
• Heix, J., Vente, A., Voit, R., Budde, A., Michaelidis, T. M., and Grummt, I. (1998). Mitotic silencing of human rRNA synthesis: inactivation of the promoter selectivity factor SL1 by cdc2/cyclin B-mediated phosphorylation. EMBO J. 17, 7373-81.
• Helin, K. (1998). Regulation of cell proliferation by the E2F transcription factors. Curr. Opin. Genet. Dev. 8, 28-35.
• Hennig, G., Behrens, J., Truss, M., Frisch, S., Reichmann, E., and Birchmeier, W. (1995). Progression of carcinoma cells is associated with alterations in chromatin structure and factor binding at the E-cadherin promoter in vivo. Oncogene 11, 475-484.
• Hennig, G., Lowrick, O., Birchmeier, W., and Behrens, J. (1996). Mechanisms identified in the transcriptional control of epithelial gene expression. J. Biol. Chem. 271, 595-602.
• Henricksen, L. A., Carter, T., Dutta, A., and Wold, M. S. (1996). Phosphorylation of human replication protein A by the DNA-dependent protein kinase in involved in the modulation of DNA replication. Nucleic Acids Res. 24, 3107-3112.
• Henricksen, L. A., Umbricht, C. B., and Wold, M. S. (1994). Recombinant replication protein A: expression, complex formation, and functional characterization. J. Biol. Chem. 269, 11121-11132.
• Hermeking, H., Lengauer, C., Polyak, K., He, T.-C., Zhang, L., Thiagalingam, S., Kinzler, K. W., and Vogelstein, B. (1997). 14-3-3s is a p53-regulated inhibitor of G2/M progression. Molecular Cell 1, 3-11.
• Hirai, H., and Sherr, C. J. (1996). Interaction of D-type cyclins with a novel myb-like transcription factor, DMP1. Mol. Cell. Biol. 16, 6457-6467.
• Hoffman, I., Clarke, P. R., Marcote, M. J., Karsenti, E., and Draetta, G. (1993). Phosphorylation and activation of human cdc25C by cdc2-cyclin B and its involvement in the self-amplification of MPF at mitosis. EMBO J. 12, 53-63.
• Holland, J. H. (1986). Escaping brittlemess: The possibilities of general-purpose learning algorithms applied to parallel rule-based systems. In Machine learning: An artificial intelligence approach, R. S. Michalski, J. G. Carbonell and T. M. Mitchell, eds. (Los Altos, CA: Morgan Kaufman), pp. 593-623.
• Honda, R., Tanaka, H., and Yasuda, H. (1997). Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53. FEBS Lett. 420, 25-27.
• Honda, R., and Yasuda, H. (1999). Association of p19ARF with Mdm2 inhibits ubiquitin ligase activity of Mdm2 for tumor suppressor p53. EMBO J. 18, 22-27.
• Hupp, T. R., and Lane, D. P. (1994). Regulation of the cryptic sequence-specific DNA-binding function of p53 by protein kinases. Cold Spring Harbor Symp. Quant. Biol. 59, 195-206.
• Inoue, K., Roussel, M. F., and Sherr, C. J. (1999). Induction of ARF tumor suppressor gene expression and cell cycle arrest by transcription factor DMP1. Proc. Natl. Acad. Sci. U S A 96, 3993-3998.
• Inoue, K., and Sherr, C. J. (1998). Gene expression and cell cycle arrest mediated by transcription factor DMP1 is antagonized by D-type cyclins through a cyclin-dependent-kinase-independent mechanism. Mol. Cell. Biol. 18, 1590-1600.
• Jackman, M., Firth, M., and Pines, J. (1995). Human cyclins B1 and B2 are localized to strikingly different structures: B1 to microtubules, B2 primarily to the Golgi apparatus. EMBO J. 14, 1646-1654.
• Jackman, M. R., and Pines, J. N. (1997). Cyclins and G2/M transition. Cancer Surveys 29, 47-73.
• Jayaraman, L., Moorthy, N. C., Murthy, K. G., Manley, J. L., Bustin, M., and Prives, C. (1998). High mobility group protein-1 (HMG-1) is a unique activator of p53. Genes Dev. 12, 462-472.
• Jin, S., Kharbanda, S., Mayer, B., Kufe, D., and Weaver, D. T. (1997). Binding of Ku and c-Abl at the kinase homology region of DNA-dependent protein kinase catalytic subunit. J. Biol. Chem. 272, 24763-24766.
• Jones, C. J., and Wood, R. D. (1993). Preferential binding of the xeroderma pigmentosum group A complementing protein to damaged DNA. Biochemistry 32, 12096-12104.
• Juven, T., Barak, Y., Zauberman, A., George, D. L., and Oren, M. (1993). Wild type p53 can mediate sequence-specific transactivation of an internal promoter within the mdm2 gene. Oncogene 8, 3411-3416.
• Kamijo, T., Weber, J. D., Zambetti, G., Zindy, F., Roussel, M. F., and Sherr, C. J. (1998). Funcional and physical interactions of the ARF tumor suppressor with p53 and Mdm2. Proc. Natl. Acad. Sci. U S A 95, 8292-8297.
• Kapoor, M., and Lozano, G. (1998). Functional activation of p53 via phosphorylation following DNA damage by UV but not g radiation. Proc. Natl. Acad. Sci. U S A 95, 2835-2837.
• Karlseder, J., Rotheneder, H., and Wintersberger, E. (1996). Interaction of Sp1 with the growth- and cell cycle-regulated transcription factor E2F. Mol. Cell. Biol. 16, 1659-1667.
• Kastan, M. B., Zhan, Q., El-Deiry, W. S., Carrier, F., Jacks, T., Walsh, W. V., Plunkett, B. S., Vogelstein, B., and Fornace, A. J. J. (1992). A mammalian cell cycle checkoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia. Cell 71, 587-597.
• Kearsey, J. M., Coates, P. J., Prescott, A. R., Warbrick, E., and Hall, P. A. (1995). Gadd45 is a nuclear cell cycle regulated protein which interacts with p21Cip1. Oncogene 11, 1675-1683.
• Kelman, Z. (1997). PCNA: structure, functions and interactions (Review). Oncogene 14, 629-640.
• Kharbanda, S., Pandey, P., Jin, S., Inoue, S., Bharti, A., Yuan, Z.-M., Weichselbaum, R., Weaver, D., and Kufe, D. (1997). Functional interaction between DNA-PK and c-Abl in response to DNA damage. Nature 386, 732-735.
• Kim, D. K., Stigger, E., and Lee, S.-H. (1996). Role of the 70-kDa subunit of human replication protein A (I). Single-stranded DNA binding activity, but not polymerase stimulatory activity, is required for DNA replication. J. Biol. Chem. 271, 15124-15129.
• Knippschild, U., Milne, D. M., Campbell, L. E., DeMaggio, A. J., Christenson, E., Hoekstra, M., and Meek, D. W. (1997). p53 is phosphorylated in vitro and in vivo by the delta and epsilon isoforms of casein kinase 1 and enhances the level of casein kinase 1 delta in response to topoisomerase-directed drugs. Oncogene 15, 1727-1736.
• Ko, L. J., Shieh, S.-Y., Chen, X., Jayaraman, L., Tamai, K., Taya, Y., Prives, C., and Pan, Z.-Q. (1997). p53 is phosphorylated by CDK7-cyclin H in a p36MAT1-dependent manner. Mol. Cell. Biol. 17, 7220-7229.
• Kohn, K. W. (1998). Functional capabilities of molecular network components controlling the mammalian G1/S cell cycle phase transition. Oncogene 16, 1065-1075.
• Krek, W., Xu, G., and Livingston, D. M. (1995). Cyclin A-kinase regulation of E2F-1 DNA binding function underlies suppresion of an S phase checkpoint. Cell 83, 1149-1158.
• Kubbatat, M. H. G., Jones, S. N., and Vousden, K. H. (1997). Regulation of p53 stability by Mdm2. Nature 387, 299-303.
• Kussie, P. H., Gorina, S., Marechal, V., Elenbaas, B., Moreau, J., Levine, A. J., and Pavletich, N. P. (1996). Structure of the MDM2 oncoprotein bound to the p53 tumor suppressor transactivation domain. Science 274, 948-953.
• LaBaer, J., Garrett, M. D., Stevenson, L. F., Slingerland, J. M., Sandhu, C., Chou, H. S., Fattaey, A., and Harlow, E. (1997). New functional activities for the p21 family of CDK inhibitors. Genes Dev. 11, 847-862.
• Le Cam, L., Polanowska, J., Fabbrizio, E., Olivier, M., Philips, A., Eaton, E. N., Classon, M., Geng, Y., and Sardet, C. (1999). Timing of cyclin E gene expression depends on the regulated association of a bipartite repressor element with a novel E2F complex. EMBO J. 18, 1878-1890.
• Lee, C.-W., Sorensen, T. S., Shikama, N., and La Thangue, N. B. (1998). Functional interplay between p53 and E2F through co-activator p300. Oncogene 16, 2695-2710.
• Lee, J. O., Russo, A. A., and Pavletich, N. P. (1998). Structure of the retinoblastoma tumour-suppressor pocket domain bound to a peptide from HPV E7. Nature 391, 859-865.
• Lee, K. S., Grenfell, T. Z., Yarm, F. R., and Erickson, R. L. (1998). Mutation of the polo-box disrupts localization and mitotic functions of the mammalian polo kinase Plk. Proc. Natl. Acad. Sci. U S A 95, 9301-9306.
• Leveillard, T., and Wasylyk, B. (1997). The MDM2 C-terminal region binds to TAFII250 and is required for MDM2 regulation of the cyclin A promoter. J. Biol. Chem. 272, 30651-61.
• Levin, D. S., Bai, W., Yan, N., O'Donnell, M., and Tomkinson, A. E. (1997). An interaction between DNA ligase I and proliferating cell nuclear antigen: implications for Okazaki fragment syntheses and joining. Proc. Natl. Acad. Sci. U S A 94, 12863-12868.
• Lewis, J. M., and Schwartz, M. A. (1998). Integrins regulate the association and phosphorylation of paxillin by c-Abl. J. Biol. Chem. 273, 14225-14230.
• Li, L., Elledge, S. J., Peterson, C. A., Bales, E. S., and Legerski, R. J. (1994). Specific association between the human DNA repair proteins XPA and ERCC1. Proc. Natl. Acad. Sci. U S A 91, 5012-5016.
• Li, R.-Y., Calsou, P., Jones, C. J., and Salles, B. (1998). Interactions of the transcription/DNA repair factor TFIIH and XP repair proteins with DNA lesions in a cell-free repair assay. J. Mol. Biol. 281, 211-218.
• Lieber, M. R., Grawunder, U., Wu, X., and Yaneva, M. (1997). Tying loose ends: roles of Ku and DNA-dependent protein kinase in the repair of double-strand breaks. Curr. Opin. Genet. Devel. 7, 99-104.
• Lill, N. L., Grossman, S. R., Ginsberg, D., DeCaprio, J., and Livingston, D. M. (1997). Binding and modulation of p53 by p300/CBP coactivators. Nature 387, 823-827.
• Lin, S.-Y., Black, A. R., Kostic, D., Pajovic, S., Hoover, C. N., and Azizkhan, J. C. (1996). Cell cycle-regulated association of E2F1 and Sp1 is related to their functionl interaction. Mol. Cell. Biol. 16, 1668-1675.
• Lin, Y. L., Chen, C., Keshav, K. F., Winchester, E., and Dutta, A. (1996). Dissection of functional domains of the human DNA replication protein complex replication protein A. J. Biol. Chem 271, 17190-17198.
• Liu, F., Stanton, J. J., Wu, Z., and Piwnica-Worms, H. (1997). The human myt1 kinase preferentially phosphorylates cdc2 on threonine 14 and localizes to the endoplasmic reticulum and Golgi complex. Mol. Cell. Biol. 17, 571-583.
• Lu, H., Fisher, R., Bailey, P., and Levine, A. (1997). The CDK7-cycH-p36 complex of TFIIH phosphorylates p53, enhancing its sequence-specific DNA binding activity in vitro. Mol. Cell. Biol. 17, 5923-5934.
• Lu, H., Taya, Y., Ikeda, M., and Levine, A. J. (1998). Ultraviolet radiation, but not g radiation or etoposide-induced DNA damage, results in the phosphorylation of the murine p53 protein at serine-389. Proc. Natl. Acad. Sci. U S A 95, 6399-6402.
• Lukas, J., Herzinger, T., Hansen, K., Moroni, M. C., Resnitzky, D., Helin, K., Reed, S. I., and Bartek, J. (1997). Cyclin E-induced S phase without activation of the pRb/E2F pathway. Genes Dev. 11, 1479-1492.
• Lundberg, A. S., and Weinberg, R. A. (1998). Functional inactivation of the retinoblastoma protein requires sequential modification by at least two distinct cyclin-cdk complexes. Mol. Cell. Biol. 18, 753-761.
• Luo, R. X., Postigo, A. A., and Dean, D. C. (1998). Rb interacts with histone deacetylase to repress transcription. Cell 92, 463-473.
• Maki, C. G., Huibregtse, J. M., and Howley, P. M. (1996). In vivo ubiquitination and proteasome-mediated degradation of p53. Cancer Res. 56, 2649-2654.
• Martin, K., Trouche, D., Hagemeier, C., Sorensen, T. S., La Thangue, N. B., and Kouzarides, T. (1995). Stimulation of E2F1/DP1 transcriptional activity by MDM2 oncoprotein. Nature 375, 691-4.
• Masson, M., Niedergang, C., Schreiber, V., Muller, S., Menissier-de Murcia, J., and de Murcia, G. (1998). XRCC1 is specifically associate with poly(ADP-ribose) polymerase and negatively regulates its activity following DNA damage. Mol. Cell. Biol. 18, 3563-3571.
• Matsunaga, T., Park, C. H., Bessho, R., Mu, D., and Sancar, A. (1996). Replication protein A confers structure-specific endonuclease activities to the XPF-ERCC1 and XPG subunits of human DNA repair excision nuclease. J. Biol. Chem 271, 11047-11050.
• Matsuoka, S., Yamaguchi, M., and Matsukage, A. (1994). D-type cyclin-binding regions of proliferating cell nuclear antigen. J. Biol. Chem. 269, 11030-11036.
• Matsuura, I., and Wang, J. H. (1996). Demonstration of cyclin-dependent kinase inhibitory serine/threonine kinase in bovine thymus. J. Biol. Chem. 271, 5443-5450.
• Mayo, L. D., Turchi, J. J., and Berberich, S. J. (1997). Mdm2 phosphorylation by DNA-dependent protein kinase prevents interaction with p53. Cancer Res. 57, 5013-5016.
• Mayol, X., and Grana, X. (1998). The p130 pocket protein: keeping order at cell cycle exit/re-entrance transitions. Front. Biosci. 3, d11-24.
• McAdams, H. H., and Shapiro, L. (1995). Circuit simulation of genetic networks. Science 269, 650-656.
• Meek, D. W. (1998). Multisite phosphorylation and the integration of stress signals at p53. Cell. Signal. 10, 159-166.
• Midgley, C. A., and Lane, D. P. (1997). p53 protein stability in tumour cells is not determined by mutation but is dependent on Mdm2 binding. Oncogene 15, 1179-89.
• Miller, S. D., Moses, K., Jayaraman, L., and Prives, C. (1997). Complex formation between p53 and replication protein A inhibits the sequence-specific DNA binding of p53 and is regulated by single-stranded DNA. Mol. Cell. Biol. 17, 2194-2201.
• Milne, D., Campbell, D., Caudwell, F., and Meek, D. (1994). Phosphorylation of the tumor suppressor protein p53 by mitogen-activated protein kinases. J Biol Chem 269, 9253-9260.
• Milne, D., Campbell, L., Campbell, D., and Meek, D. (1995). p53 is phosphorylated in vitro and in vivo by an ultraviolet radiation-induced protein kinase characteristic of the c-Jun kinase, JNK1. J Biol Chem 270, 5511-5518.
• Milne, G. T., and Weaver, D. T. (1993). Dominant negative alleles of RAD52 reveal a DNA repair/recombination complex including Rad51 and Rad52. Genes Dev. 7, 1755-1765.
• Moggs, J. G., Yarema, K. J., Essigmann, J. M., and Wood, R. D. (1996). Analysis of incision sites produced by human cell extracts and purified proteins during nucleotide excision repair of a 1,3-intrastrand d(GpTpG)-cisplatin adduct. J. Biol. Chem. 271, 7177-7186.
• Momand, J., Zambetti, G. P., Olson, D. C., George, D., and Levine, A. J. (1992). The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p5 -mediated transactivation. Cell 69, 1237-1245.
• Montes, R., Luna, O., Tabor, A. D., Eberspaecher, H., Hulboy, D. L., L., W. L., Colman, M. S., Finlay, C. A., and G., L. (1996). The organization and expression of the mdm2 gene. Genomics 33, 352-357.
• Morgan, D. O. (1995). Principles of CDK regulation. Nature 374, 131-134.
• Morris, G. F., Bischoff, J. R., and Mathews, M. B. (1996). Transcriptional activation of the human proliferating cell nuclear antigen promoter by p53. Proc. Natl. Acad. Sci. U S A 93, 895-899.
• Mossi, R., Jonsson, Z. O., Allen, B. L., Hardin, S. H., and Hubacher, U. (1997). Replication factor C interacts with the C-terminal side of proliferating cell nuclear antigen. J. Biol. Chem. 272, 1769-1776.
• Mu, D., Hsu, D. S., and Sancar, A. (1996). Reaction-mechanism of human DNA-repair excision nuclease. J. Biol. Chem. 271, 8285-8294.
• Mu, D., Park, C.-H., Matsunaga, R., Hsu, D. S., Reardon, J. T., and Sancar, A. (1995). J. Biol. Chem. 270, 2415-2418.
• Mu, D., and Sancar, A. (1997). Model for XPC-independent transcription-coupled repair of pyrimidine dimers in humans. J. Biol. Chem. 272, 7570-7573.
• Mysung, K., He, D. M., Lee, S. E., and Hendrickson, E. A. (1997). EMBO J., 3172-3184.
• Myung, K., Braastad, C., He, D. M., and Hendrickson, E. A. (1998). KARP-1 is induced by DNA damage in a p53- and ataxia telangiectasia mutated-dependent fashion. Proc. Natl. Acad. Sci. U S A 95, 7664-7669.
• Nagelhus, T. A., Haug, T., Singh, K. K., Keshav, K. F., Skorpen, F., Otterlei, M., Bharati, S., Lindmo, T., Benichou, S., Benarous, R., and Krokan, H. E. (1997). A sequence in the N-terminal region of human uracil-DNA glycosylase with homology to XPA interacts with the C-terminal part of the 34-kDa subunit of replication protein A. J. Biol. Chem. 272, 6561-6566.
• Nakagawa, K., Taya, Y., Tamai, K., and Yamaizumi, M. (1999). Requirement of ATM in phosphorylation of the human p53 protein at serine 15 following DNA double-strand breaks. Mol. Cell. Biol. 19, 2828-2834.
• Nakajima, T., Uchida, C., Anderson, S. F., Lee, C.-G., Hurwitz, J., Parvin, J. D., and Montminy, M. (1997). RNA helicase A mediates association of CBP with RNA polymerase II. Cell 90, 1107-1112.
• Nead, M. A., Baglia, L. A., Antinore, M. J., Ludlow, J. W., and McCance, D. J. (1998). Rb binds c-Jun and activates transcription. EMBO J. 17, 2342-2352.
• New, J., Sugiyama, T., Zaitseva, E., and Kowalczykowski, S. (1998). Rad52 protein stimulates DNA strand exchange by Rad51 and replication. Nature 391, 407-410.
• Niu, H., Erdjumeni-Bromage, H., Pan, Z.-Q., Lee, S.-H., Tempst, P., and Hurwitz, J. (1997). Mapping of amino acid residues in the p34 subunit of human single-stranded DNA-binding protein phosphorylated by DNA-dependent protein kinase and cdc2 kinase in vitro. J. Biol. Chem. 272, 12634-12641.
• Ogryzko, V. V., Schiltz, R. L., Russanova, V., Howard, B. H., and Nakatani, Y. (1996). The transcriptional coactivators p300 and CBP are histone acetyltransferases. Cell 87, 953-959.
• Ouchi, T., Monteiro, A. N. A., August, A., Aaronson, S. A., and Hanafusa, H. (1998). BRCA1 regulates p53-dependent gene expression. Proc. Natl. Acad. Sci. U S A 95, 2302-2306.
• Pagano, M., Theodoras, A. M., Tam, S. W., and Draetta, G. F. (1994). Cyclin D1-mediated inhibition of repair and replicative DNA synthesis in human fibroblasts. Genes Dev. 8, 1627-1639.
• Pan, Z.-Q., and Hurwitz, J. (1993). Reconstitution of cyclin-dependent cdc2 and cdk2 kinase activities in vitro. J. Biol. Chem. 268, 20443-20451.
• Park, M. S., Ludwig, D. L., Stigger, E., and Lee, S. H. (1996). Physical interaction between human RAD52 and RPA is required for homologous recombination in mammalian cells. J. Biol. Chem. 271, 18996-19000.
• Peng, C.-Y., Graves, P. R., Ogg, S., Thoma, R. S., Byrnes, M. J. I., Wu, Z., Stephenson, M. T., and Piwnica-Worms, H. (1998). C-TAK1 protein kinase phosphorylates human Cdc25C on serine 216 and promotes 14-3-3 protein binding. Cell Growth Diff. 9, 197-208.
• Peng, C.-Y., Graves, P. R., Thoma, R. S. W., Z., Shaw, A. S., and Piwnica-Worms, H. (1997). Mitotic and G2 checkpoint control: regulation of 14-3-3 protein binding by phosphorylation of Cdc25C on serine-216. Science 277, 1501-1505.
• Perkins, N. D., Felzien, L. K., Betts, J. C., Leung, K., Beach, D. H., and Nabel, G. J. (1997). Regulation of NF-kB by cyclin-dependent kinases associated with the p300 coactivator. Science 275, 523-527.
• Pines, J., and Hunter, T. (1994). The differential localization of human cyclins A and B is due to a cytoplasmic retention signal in cyclin B. EMBO J. 13, 3772-3781.
• Pomerantz, J., Schreiber-Agus, N., Liegeois, N. J., Silverman, A., Alland, L., Chin, L., Potes, J., Chen, K., Orlow, I., Lee, H.-W., Cordon-Cardo, C., and DePinho, R. A. (1998). The ink4a tumor suppressor gene product, p19arf, interacts with MDM2 and neutralizes MDM2's inhibition of p53. Cell 92, 713-723.
• Prives, C. (1998). Signaling to p53:breaking the MDM2-p53 circuit. Cell 95, 5-8.
• Reihsaus, E., Kohler, M., Kraiss, S., Oren, M., and Montenarh, M. (1990). Regulation of the level of the oncoprotein p53 in non-transformed and transformed cells. Oncogene 5, 137-145.
• Roth, J., Dobbelstein, M., Freedman, D., Shenk, T., and Levine, A. J. (1998). Nucleo-cytoplasmic shuttling of the hdm2 oncoprotein regulates the levels of the p53 protein via a pathway used by the human HIV rev protein. EMBO J. 17, 554-564.
• Roy, S., McPherson, R. A., Apolloni, A., Yan, J., Lane, A., Clyde-Smith, J., and Hancock, J. F. (1998). 14-3-3 facilitates Ras-dependent Raf-1 activation in vitro and in vivo. Mol. Cell. Biol. 18, 3947-3955.
• Ruscetti, T., Lehnert, B., Halbrook, J., Le Trong, H., Hoekstra, M., Chen, D., and Peterson, S. (1998). Stimulation of the DNA-dependent protein kinase by poly(ADP-ribose) polymerase. J Biol Chem 273, 14461-14467.
• Saijo, M., Kuraoka, I., Masutani, C., Hanaoka, F., and Tanaka, K. (1996). Sequential binding of DNA repair proteins RPA and ERCC1 to XPA in vitro. Nucleic Acids Res. 24, 4719-4724.
• Sakaguchi, K., Herrera, J. E., Saito, S., Miki, T., Bustin, M., Vassilev, A., Anderson, C. W., and Appella, E. (1998). DNA damage activates p53 through a phosphorylation-acetylation cascade. Genes Dev. 12, 2831-2841.
• Sakaguchi, K., Sakamoto, H., Lewis, M. S., Anderson, C. W., Erickson, J. W., Appella, E., and Xie, D. (1997). Phosphorylation of serine 392 stabilizes the tetramer formation of tumor suppressor protein p53. Biochemistry 36, 10117-10124.
• Sanchez, Y., Wong, C., Thoma, R. S., Richman, R., Wu, Z., Piwnica-Worms, H., and Elledge, S. J. (1997). Conservation of the Chk1 checkpoint pathway in mammals: linkage of DNA damage to Cdk regulation through Cdc25. Science 277, 1497-1501.
• Scully, R., Chen, J., Ochs, R. L., Keegan, K., Hoekstra, M., Feunteun, J., and Livingston, D. M. (1997). Dynamic changes of BRCA1 subnuclear location and phosphorylation state are initiated by DNA damage. Cell 90, 425-435.
• Scully, R., Chen, J., Plug, A., Xiao, Y., Weaver, D., Feunteun, J., Ashley, T., and Livingston, D. M. (1997). Association of BRCA1 with Rad51 in mitotic and meiotic cells. Cell 88, 265-275.
• Selvakumaran, M., K., L. H., Sjin, R. T. T., Reed, J. C., Liebermann, D., and Hoffman, B. (1994). Mol. Cell. Biol. 14, 2352-2356.
• Selvakumaran, M., Lin, H.-K., Miyatashita, T., Wang, H. G., Krajewski, S., Reed, J. C., Hoffman, B., and Liebermann, D. (1994). Immediate early up-regulation of bax expression by p53 but not TGFb1: a paradigm for distinct apoptotic pathways. Oncogene 9, 1791-8.
• Serizawa, H. (1998). Cyclin-dependent kinase inhibitor p16INK4A inhibits phosphorylation of RNA polymerase II by general transcription factor TFIIH. J. Biol. Chem. 273, 5427-5430.
• Shan, B., Farmer, A. A., and Lee, W. H. (1996). The molecular basis of E2F-1/DP-1-induced S-phase entry and apoptosis. Cell Growth Differ. 7, 689-697.
• Shao, R.-G., Cao, C.-X., Zhang, H., Kohn, K. W., Wold, M. S., and Pommier, Y. (1999). Replication-mediated DNA damage by camptothecin induces phosphorylation of RPA by DNA-dependent protein kinase and dissociates DNA-PK/RPA complexes. EMBO J. 18, 1397-1406.
• Sheaff, R., Groudine, M., Gordon, M., Roberts, J., and B/, C. (1997). Cyclin E-cdk2 is a regulator of p27kip1. Genes Dev. 11, 1464-1478.
• Sherr, C. J. (1998). Tumor surveillance via the ARF-p53 pathway. Genes Dev. 12, 2984-2991.
• Shieh, S., Ikeda, M., Taya, Y., and Prives, C. (1997). DNA damage-induced phosphorylation of p53 alleviates inhibition by MDM2. Cell 91, 325-334.
• Shieh, S.-Y., Taya, Y., and Prives, C. (1999). DNA damage-inducible phosphorylation of p53 at N-terminal sites including a novel site, Ser20, requires tetramerization. EMBO J. 18, 1815-1823.
• Shivakumar, C. V., Brown, D. R., Deb, S., and Deb, S. F. (1995). Wild-type human p53 transactivates the human proliferating cell nuclear antigen promoter. Mol. Cell. Biol. 15, 6785-6795.
• Siliciano, J. D., Canman, C. E., Taya, Y., Sakaguchi, K., Appella, E., and Kastan, M. B. (1997). DNA damage induces phosphorylation of the amino terminus of p53. Genes Dev. 11, 3471-3481.
• Simbulan, C., Suzuki, M., Izuta, S., Sakurai, T., Savoysky, E., Kojima, K., Miyahara, K., Shizuta, Y., and Yoshida, S. (1993). Poly(ADP-ribose) polymerase stimulates DNA polymerase alpha by physical association. J Biol Chem 268, 93-99.
• Simbulan-Rosenthal, C. M., Rosenthal, D. S., Boulares, A. H., Hickey, R. J., Malkas, L. H., Coll, J. M., and Smulson, M. E. (1998). Regulation of the expression of recruitment of components of the DNA synthesome by poly(ADP-ribose) polymerase. Biochemistry 37, 9363-9370.
• Sionov, R. V., Moallem, E., Berger, M., Kazaz, A., Gerlitz, O., Ben-Neriah, Y., Oren, M., and Haupt, Y. (1999). c-Abl neutralizes the inhibitory effect of Mdm2 on p53. J. Biol. Chem. 274, 8371-8374.
• Smider, V., Rathmell, W. K., Brown, G., Lewis, S., and Chu, G. (1998). Failure of hairpin-ended and nicked DNA to activate DNA-dependent protein kinase: implications for V(D)J recombination. Mol. Cell. Biol. 18, 6853-6858.
• Smith, M. L., Chen, I. T., Zhan, Q., Bae, I., Chen, C. Y., Gilmer, T. M., Kastan, M. B., O'Connor, P. M., and Fornace, A. J. J. (1994). Interaction of the p53-regulated protein Gadd45 with proliferating cell nuclear antigen. Science 266, 1376-80.
• Sorensen, T. S., Girling, R., Lee, C. W., Gannon, J., Bandara, L. R., and La Thangue, N. B. (1996). Functional interaction between DP-1 and p53. Mol. Cell. Biol. 16, 5888-5895.
• Stiegler, P., De Luca, A., Bagella, L., and Giordano, A. (1998). The COOH-terminal region of pRb2/p130 binds to histone deacetylase 1 (HDAC1), enhancing transcriptional repression of the E2F-dependent cyclin A promoter. Cancer Res. 58, 5049-5052.
• Stigger, E., Dean, F. B., Hurwitz, J., and Lee, S.-H. (1994). Reconstitution of functional human single-stranded DNA binding protein from individual subunits expressed by recombinant baculoviruses. Proc. Natl. Acad. Sci. U S A 91, 579-583.
• Stigger, E., Drissi, R., and Lee, S.-H. (1998). Functional analysis of human replication protein A in nucleotide excision repair. J. Biol. Chem. 273, 9337-9343.
• Stott, F. J., Bates, S., James, M. C., McConnell, B. B., Starborg, M., Brookes, S., Palmero, I., Ryan, K., Hara, E., Vousden, K. H., and Peters, G. (1998). The alternative product from the human CDKN2A locus,
• p14(ARF), participates in a regulatory feedback loop with
• p53 and MDM2. EMBO J. 17, 5001-5014.
• Sugasawa, K., Ng, J. M. Y., Masutani, C., Iwai, S., van der Spek, P. J., Eker, A. P. M., Hanaoka, F., Bootsma, D., and Hoeijmakers, J. H. J. (1998). Xeroderma pigmentosum group C protein complex is the initiator of global genome nucleotide excision repair. Molecular Cell 2, 223-232.
• Sugasawa, K., Ng, J. M. Y., Masutani, C., Maekawa, T., Uchida, A., van der Spek, P. J., Eker, A. P. M., Rademakers, S., Visser, C., Aboussekhra, A., Wood, R. D., Hanaoka, F., Bootsma, D., and Hoeijmakers, J. H. J. (1997). Two human homologs of Rad23 are functionally interchangeable in complex formation and stimulation of XPC repair activity. Mol. Cell. Biol. 17, 6924-6931.
• Takenaka, I., Morin, F., Seizinger, B., and Kley, N. (1995). Regulation of the sequence-specific DNA binding function of p53 by protein kinase C and protein phosphatases. J Biol Chem 270, 5405-5411.
• Tan, X. Q., and Wang, J. Y. J. (1998). The caspase-RB connection in cell death. Trends Cell Biol. 8, 116-120.
• Tao, W., and Levine, A. J. (1999). Nucleocytoplasmic shuttling of oncoprotein Hdm2 is required for Hdm2-mediated degradation of p53. Proc. Natl. Acad. Sci. U S A 96, 3077-3080.
• Tassan, J. P., Schultz, S. J., Bartek, J., and Nigg, E. A. (1994). Cell cycle analysis of the activity, subcellular localization, and subunit composition of human CAK (CDK-activating kinase). J. Cell Biol. 127, 467-478.
• Terada, Y., Tatsuka, M., Jinno, S., and Okayama, H. (1995). Requirement for tyrosine phosphorylation of cdk4 in G1 arrest induced by ultraviolet irradiation. Nature 376, 358-362.
• Tevosian, S. G., Shih, H. H., Mendelson, K. G., Sheppard, K. A., Paulson, K. E., and Yee, A. S. (1997). HBP1 - an HMG box transcriptional repressor that is targeted by the retinoblastoma family. Genes Dev. 11, 383-396.
• Thomas, A., and White, E. (1998). Suppression of the p300-dependent mdm2 negative-feedback loop induces the p53 apoptotic function. Genes Dev. 12, 1975-1985.
• Thorson, J. A., Yu, L. W. K., L., H. A., Shih, N.-Y., Graves, P. R., Tanner, J. W., Allen, P. M., Piwnica-Worms, H., and Shaw, A. S. (1998). 14-3-3 proteins are required for maintenance of Raf-1 phosphorylation and kinase activity. Mol. Cell. Biol. 18, 5229-5238.
• Thut, C. J., Goodrich, J. A., and Tjian, R. (1997). Repression of p53-mediated transcription by MDM2: a dual mechanism. Genes Dev. 11, 1974-86.
• Tibbetts, R. S., Brumbaugh, K. M., Williams, J. M., Sarkaria, J. N., Cliby, W. A., Shieh, S.-Y., Taya, Y., Prives, C., and Abraham, R. T. (1999). A role for ATR in the DNA damage-induced phosphorylation of p53. Genes Dev. 13, 152-157.
• Tinker, R. L., Kassavetis, G. A., and Geiduschek, E. P. (1994). EMBO J. 13, 5339-5337.
• Trimarchi, J. M., Fairchild, B., Verona, R., Mogberg, K., Andon, N., and Lees, J. A. (1998). E2F-6, a member of the E2F family that can behave as a transcriptional repressor. Proc. Natl. Acad. Sci. USA 95, 2850-2855.
• Tzivion, G., Luo, Z., and Avruch, J. (1998). A dimeric 14-3-3 protein is an essential cofactor for Raf kinase activity. Nature 394, 88-92.
• Unger, T., Juven-Gershon, T., Moallem, E., Berger, M., Sionov, R. V., Lozano, G., Oren, M., and Haupt, Y. (1999). Critical role of Ser20 of human p53 in the negative regulation of p53 by Mdm2. EMBO J. 18, 1805-1814.
• Vaziri, H., D., W. M., Allsopp, R. C., Davison, T. S., Wu, Y.-S., Arrowsmith, C. H., Poirier, G. G., and Benchimol, S. (1997). ATM-dependent telomere loss in aging human diploid fibroblasts and DNA damage lead to the post-translational activation of p53 protein involving poly(ADP-ribose) polymerase. EMBO J. 19, 6018-6033.
• Voitenleitner, C., Rehfuess, C., Hilmes, M., O'Rear, L., Liao, P.-C., Gage, D. A., Ott, R., Nasheuer, H.-P., and Fanning, E. (1999). Cell cycle-dependent regulation of human DNA polymerase a-primase activity by phosphorylation. Mol. Cell. Biol 19, 646-656.
• Wakasugi, M., and Sancar, A. (1998). Assembly, subunit composition and footprint of human DNA repair excision nuclease. Proc. Natl. Acad. Sci. U S A 95, 6669-6674.
• Wang, S., Ghosh, R. N., and Chellappan, S. P. (1998). Raf-1 physically interacts with Rb and regulates its function: a link between mitogenic signaling and cell cycle regulation. Mol. Cell. Biol. 18, 7487-7498.
• Wang, X., Yeh, H., Schaeffer, L., Roy, R., Moncollin, V., Egly, J., Wang, Z., Freidberg, E., Evans, M., Taffe, B., Bohr, V. A., and Harris, C. C. (1995). p53 modulation of TFIIH-associated nucleotide excision repair activity. Nat Genet 10, 188-195.
• Wang, Y., and Prives, C. (1995). Increased and altered DNA binding of human p53 by S and G2/M but not G1 cyclin-dependent kinases. Nature, 88-91.
• Watanabe, G., Albanese, C., Lee, R. J., Reutens, A., Vairo, G., Henglein, B., and Pestell, R. G. (1998). Inhibition of cyclin D1 kinase activity is associated with E2F-mediated inhibition of cyclin D1 promoter activity through E2F and Sp1. Mol. Cell. Biol. 18, 3212-3222.
• Waterman, M. J. F., Stavridi, E. S., Waterman, J. L. F., and Halazonetis, T. D. (1998). ATM-dependent activation of p53 involves dephosphorylation and association with 14-3-3. Nature Genetics 19, 175-178.
• Weinberg, R. A. (1995). The retinoblastoma protein and cell cycle control. Cell 81, 323-330.
• Welch, P. J., and Wang, J. Y. J. (1995). Disruption of retinoblastoma protein function by coexpression of its C pocket fragment. Genes Dev. 9, 31-46.
• Wesierska, J., Schmid, H., and Cerni, C. (1996). ADP-ribosylation of wild-type p53 in vitro: binding of p53 to specific p533 consensus sequence prevents its modification. Biochem. Biophys. Res. Commun. 224, 96-102.
• West, R. B., Yaneva, M., and R., L. M. (1998). Productive and nonproductive complexes of Ku and DNA-dependent protein kinase at DNA termini. Mol. Cell. Biol. 18, 5908-5920.
• Whitaker, L. L., Su, H., Baskaran, R., Knudsen, E. S., and Wang, J. Y. J. (1998). Growth suppression by an E2F-binding-defective retinoblastoma protein (RB): contribution from the RB C pocket. Mol. Cell. Biol. 18, 4032-4042.
• Wold, M. S. (1997). Replication protein A: A heterotrimeric, single-stranded DNA-binding protein required for eukaryotic DNA metabolism. Annu. Rev. Biochem. 66, 61-92.
• Won, K. A., and Reed, S. I. (1996). Activation of cyclin E/cdk2 is coupled to site-specific autophosphorylation and ubiquitin-dependent degradation of cyclin E. EMBO J. 15, 4182-4193.
• Wu, X., Bayle, J. H., Olson, D., and Levine, A. J. (1993). The p53-mdm2 autoregulatory feedback loop. Genes Dev. 7, 1126-1132.
• Wu, X., Li, J., Li, X., Hsieh, C. L., Burgers, P. M., and Lieber, M. R. (1996). Processing of branched DNA intermediates by a complex of human FEN-1 and PCNA. Nucleic Acids Res. 24, 2036-2043.
• Xiao, Z.-X., Chen, J., Levine, A. J., Modjtahedi, N., Xing, J., Sellers, W. R., and Livingston, D. M. (1995). Interaction between the retinoblastoma protein and the oncoprotein MDM2. Nature 375, 694-698.
• Xu, J., and Morris, G. F. (1999). p53-mediated regulation of proliferating cell nuclear antigen expression in cells exposed to ionizing radiation. Mol. Cell. Biol. 19, 12-20.
• Xu, M., Sheppard, K. A., Peng, C. Y., Yee, A. S., and Piwnica-Worms, H. (1994). Cyclin A/CDK2 binds directly to E2F1 and inhibits the DNA-binding activity of E2F1/DP1 by phosphorylation. Mol. Cell. Biol. 14, 8420-8431.
• Yam, C. H., Ng, R. W. M., Siu, W. Y., Lau, A. W. S., and Poon, R. Y. C. (1999). Regulation of cyclin A-Cdk2 by SCF component Skp1 and F-box protein Skp2. Mol. Cell. Biol. 19, 635-645.
• Yaneva, M., Kowalewski, R., and Lieber, M. R. (1997). Interaction of DNA-dependent protein kinase with DNA and with Ku: biochemical and atomic-force microscopy studies. EMBO J. 16, 5098-5112.
• Youmell, M., Park, S. J., Basu, S., and Price, B. D. (1998). Regulation of the p53 protein by protein kinase C alpha and protein kinase C zeta. Biochem. Biophys. Res. Commun. 245, 514-518.
• Yuan, Z.-M., Huang, Y., Fan, M.-M., Sawyers, C., Kharbanda, S., and Kufe, D. (1996). Genotoxic drugs induce interaction of the c-Abl tyrosine kinase and tumor suppressor protein p53. J. Biol. Chem. 271, 26457-26460.
• Yuan, Z.-M., Huang, Y., Ishiko, T., Nakada, S., Utsugisawa, T., Kharbanda, S., Wang, R., Sung, P., Shinogara, A., Weichselbaum, R., and Kufe, D. (1998). Regulation of Rad51 function by c-Abl in response to DNA damage. J. Biol. Chem. 273, 3799-3802.
• Yuan, Z.-M., Huang, Y., Ishiko, T., Nakada, S., Utsugisawa, T., Shioya, H., Utsugisawa, Y., Yodoyama, K., Weichselbaum, R., Shi, Y., and Kufe, D. (1999). Role for p300 in stabilization of p53 in the response to DNA damage. J. Biol. Chem. 274, 1883-1886.
• Yumoto, Y., Shirakawa, H., Yoshida, M., Suwa, A., Watanabe, F., and Teraoka, H. (1998). High mobility group proteins 1 and 2 can function as DNA-binding regulatory components for DNA-dependent protein kinase in vitro. J. Biochem. 124, 519-527.
• Zarakowska, R., and Mittnacht, S. (1997). Differential phosphorylation of the retinoblastoma protein by G1/S cyclin-dependent kinases. J. Biol. Chem. 272, 12738-12746.
• Zauberman, A., Flusberg, D., Haupt, Y., Barak, Y., and Oren, M. (1995). A functional p53-responsive intronic promoter is contained within the human mdm2 gene. Nucleic Acids Res. 23, 2584-2592.
• Zernik-Kobak, M., Vasunia, K., Connelly, M., Anderson, C. W., and Dixon, K. (1997). Sites of UV-induced phosphorylation of the p34 subunit of replication protein A from HeLa cells. J. Biol. Chem. 272, 23896-23904.
• Zhan, Q., Antinore, M. J., Wang, X. W., Carrier, F., Smith, M. L., Harris, C. C., and Fornace, A. J. J. (1999). Association with Cdc2 and inhibition of Cdc2/Cyclin B1 kinase activity by the p53-regulated protein Gadd45. Oncogene (in press).
• Zhan, Q., Chen, I.-T., Antinore, M. J., and Fornace, A. J. J. (1998). Tumor suppressor p53 can participate in transcriptional induction of the GADD45 promoter in the absence of direct DNA binding. Mol. Cell. Biol. 18, 2768-2778.
• Zhan, Q., Fan, S., Bae, I., Guillouf, C., Liebermann, D. A., O'Connor, P. M., and Fornace, A. J., Jr. (1994). Induction of bax by genotoxic stress in human cells correlates with normal status and apoptosis [published erratum appears in Oncogene 1995 Mar 16;10(6):1259]. Oncogene 9, 3743-3751.
• Zhan, Q., Lord, K. A., Alamo, I., Jr., Hollander, M. C., Carrier, F., Ron, D., Kohn, K. W., Hoffman, B., Liebermann, D. A., and Fornace, A. J., Jr. (1994). The gadd and MyD genes define a novel set of mammalian genes encoding acid proteins that synergistically suppress cell growth. Mol Cell Biol 14, 2361-71.
• Zhang, H., Hannon, G. J., and Beach, D. (1994). p21-containing cyclin kinases exist in both active and inactive states. Genes Dev. 8, 1750-1758.
• Zhang, H., Kobayashi, R., Galaktionov, K., and Beach, D. (1995). p19Skp1 and p45Skp2 are essential elements of the cyclin A/CDK2 S-phase kinase. Cell 82, 915-925.
• Zhang, H., Somasundaram, K., Peng, Y., Tian, H., Zhang, H., Bi, D., Wever, B. L., and El-Deiry, W. S. (1998). BRCA1 physically associates with p53 and stimulates its transcriptional activity. Oncogene 16, 1713-1721.
• Zhang, H., Xiong, Y., and Beach, D. (1993). Proliferating cell nuclear antigen and p21 are components of multiple cell cycle kinase complexes. Mol. Cell. Biol. 4, 897-906.
• Zhang, Y., Xiong, Y., and Yarbrough, W. G. (1998). ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways. Cell 92, 725-734.
• Zhu, L., Xie, E., and Chang, L. S. (1995). Differential roles of two tandem E2F sites in repression of the human p107 promoter by retinoblastoma and p107 proteins. Mol. Cell. Biol. 15, 3552-3562.

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