Replicative Senescence
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Mirit I. Aladjem
Implemented by : Margot Sunshine
This molecular interaction map depicts the regulatory circuits that regulate apoptosis and senescence following DNA damage and appropriate DNA replication.
In mitotic cells, a network of regulatory interactions modulates the transcription of genes required for cell proliferation, leading to DNA replication.
These interactions are linked to biochemical pathways that prevent replication under conditions that elicit DNA breakage.
In cancer cells, the molecular interaction network shown here acts to prevent senescence and apoptosis, activate DNA replication and facilitate epithelial to mesenchymal transition.
The map accompanies the book chapter "Establishment of replicative immortality in cancer cells" in Pathobiology of Human Disease: A Dynamic Encyclopedia of Disease Mechanisms (in press).
