CellMiner™ is a web application generated by the Genomics & Bioinformatics Group, LMP, CCR, NCI
that facilitates systems biology through the retrieval and integration of the molecular and pharmacological data sets for the NCI-60 cell lines.
The NCI-60, a panel of 60 diverse human cancer cell lines used by the Developmental Therapeutics Program of the U.S. National Cancer Institute to screen over 100,000 chemical compounds and natural products (since 1990).
To cite the tool, the primary literature references are (Shankavaram, BMC Genomic, 2009 and Reinhold, Cancer Res, 2012).
Press articles reviewing CellMiner may be accessed here (NCI featured newsCancer Discovery) (CCR Connections)
(Slashdot) (NCI press release)
Press articles reviewing the Exome data set may be accessed here (Time Magazine) (NPR)
(Forbes) (Los Angeles Times)
(U.S. News Health).
Subsequent builds will include additional molecular data sets and integrative capabilities.
How to find the information you need in CellMiner using the above tabs
- NCI-60 Analysis Tools tab to access automation of several commonly done analyses (Reinhold, Cancer Res, 2012).
- Query Genomic Data tab to query the normalized data sets for information. You can search the data using single identifiers, or a list of identifiers, customize your data annotation, and select your output data format.
- Query Drug Data tab to query the drug data for information. You can search the data using single identifiers, or a list of identifiers, customize your data annotation, and select your output data format.
- Download Data Sets tab to download the entire data set, in either raw or normalized versions.
- Cell Line Metadata tab
to view metadata on the NCI-60 panel. Included are tissue type,
patient demographics, prior treatment, histology, source, ploidy, p53 status, DNA fingerprint data, etc.
- Data Set Metadata tab to get background information about each data set.
|For other bioinformatic tools and database resources from GBG go to the
Discover website home page.|
|For additional drug, dataset and molecular target data see the NCI
Developmental Therapeutics Program site.|
CellMiner Development Team
Margot Sunshine, Sudhir Varma, William Reinhold and Yves Pommier prior contributors