(-)-Nutlin-3
| Key | Value |
|---|---|
| Synonyms: | 548472-68-0 890090-75-2 CHEMBL211045 NUTLIN 3 NUTLIN-3 675576-98-4 NUTLIN (3A) NUTLIN 3A NUTLIN-3A UNII-L7C92IOE65 (-)-NUTLIN-3 (-)-NUTLIN-3 NUTLIN 3A 18585 18585 NUTLIN-3A HOMOCHIRAL 756876 NUTLIN-3A (-) |
| National Service Center# (NSC#):1,2 | 756876 |
| CAS#: | 675576-98-4 |
| PubChem#: | NA |
| Mechanism of Action: | Apo|MDM2 |
| Status: | Clinical trial |
| Molecular Formula: | C30H30Cl2N4O4 |
| Smiles: | COc1ccc(C2=N[C@H]([C@H](N2C(=O)N3CCNC(=O)C3)c4ccc(Cl)cc4)c5ccc(Cl)cc5)c(OC(C)C)c1 |
(-)-Nutlin-3 is in CellMinerCDB, a searchable tool integrating cancer cell line pharmacogenomics data to link gene and drug activity signatures.
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(-)-Nutlin-3 is in CellMiner (NCI-60),a database and query tool designed for the cancer research community to facilitate integration and study of molecular and pharmacological data for the NCI-60 cancerous cell lines.
Click Here to Access CellMiner (NCI-60)
If you use content from this page, CellMinerCDB or CellMiner (NCI-60), please cite: Luna A et al. 2021. PMID: 33196823, Rajapakse VN et al. 2018. PMID: 30553813, Luna et al. 2016., PMID: 26635141, and Reinhold et al. 2012., PMID: 22802077.
Available Data
Visit CellMinerCDB to interactively explore available pharmacogenomics data for (-)-Nutlin-3.
Visit CellMiner (NCI-60) to explore NCI-60 related analysis for (-)-Nutlin-3.
| NCI60 | GDSC-MGH-Sanger | GDSC1 drugs | GDSC2 drugs | CCLE-Broad-MIT | CTRP-Broad-MIT | NCI-DTP SCLC | PRISM-Broad-MIT | NCI60-DTP Almanac |
|---|---|---|---|---|---|---|---|---|
| 756876 | Nutlin-3a | Nutlin-3a (-) | Nutlin-3a (-) | Nutlin-3 | nutlin-3 | NA | nutlin-3 | NA |
2 Most structures have a unique NSC number but over the years a small percentage of structures or agents may have been assigned more than one NSC number. In the case of salts, different salt forms (e.g. HCl, HOAc) are designated with separate NSC numbers.
