Publications

2015-2019

RNA Sequencing of the NCI-60: Integration into CellMiner and CellMiner CDB
2019 May 21
William C. Reinhold, Sudhir Varma, Margot Sunshine, Fathi Elloumi, Kwabena Ofori-Atta, Sunmin Lee, Jane B. Trepel, Paul S. Meltzer, James H. Doroshow and Yves Pommier

A novel assay to screen siRNA libraries identifies protein kinases required for chromosome transmission
2019 August 21
Mikhail Liskovykh, Nikolay V. Goncharov, Nikolai Petrov, Vasilisa Aksenova, Gianluca Pegoraro, Laurent L. Ozbun, William C. Reinhold, Sudhir Varma, Mary Dasso, Vadim Kumeiko, Hiroshi Masumoto, William C. Earnshaw, Vladimir Larionov and Natalay Kouprina

Tyrosyl-DNA Phosphodiesterase 1 and Topoisomerase I Activities as Predictive Indicators for Glioblastoma Susceptibility to Genotoxic Agents
2019 September 23
Wenjie Wang, Monica Rodriguez-Silva, Arlet M. Acanda de la Rocha, Aizik L. Wolf, Yanhao Lai, Yuan Liu, William C. Reinhold, Yves Pommier, JeremyW. Chambers and Yuk-Ching Tse-Dinh

Quantitative Proteome Landscape of the NCI-60 Cancer Cell Lines
2019 November 22
Tiannan Guo, Augustin Luna, Vinodh N. Rajapakse, Ching Chiek Koh, Zhicheng Wu, Wei Liu, Yaoting Sun, Huanhuan Gao, Michael P. Menden, Chao Xu, Laurence Calzone, Loredana Martignetti, Chiara Auwerx, Marija Buljan, Amir Banaei-Esfahani, Alessandro Ori, Murat Iskar, Ludovic Gillet, Ran Bi, Jiangnan Zhang, Huanhuan Zhang, Chenhuan Yu, Qing Zhong, Sudhir Varma, Uwe Schmitt, Peng Qiu, Qiushi Zhang, Yi Zhu, Peter J. Wild, Mathew J. Garnett, Peer Bork, Martin Beck, Kexin Liu, Julio Saez-Rodriguez, Fathi Elloumi, William C. Reinhold, Chris Sander, Yves Pommier, and Ruedi Aebersold

Rapid proteotyping reveals cancer biology and drug response determinants in the NCI-60 cells
2018 Feb 01
Tiannan Guo, Augustin Luna, Vinodh N Rajapakse, Ching Chiek Koh, Zhicheng Wu, Michael P Menden, Yongran Cheng, Laurence Calzone, Loredana Martignetti, Alessandro Ori, Murat Iskar, Ludovic Gillet, Qing Zhong, Sudhir Varma, Uwe Schmitt, Peng Qiu, Yaoting Sun, Yi Zhu, Peter J Wild, Mathew J Garnett, Peer Bork, Martin Beck, Julio Saez-Rodriguez, William C. Reinhold, Chris Sander, Yves Pommier, Ruedi Aebersold.

CellMiner and CellMiner Cross-Database (CDB): resources for the exploration of pharmacogenomics using cancerous cell-lines
2018 March 05
William C. Reinhold and Yves Pommier.

ONC201 kills breast cancer cells in vitro by targeting mitochondria
2018 April 06
Yoshimi Endo Greer, Natalie Porat-Shliom, Kunio Nagashima, Christina Stuelten, Dan Crooks, Vishal N. Koparde, Samuel F. Gilbert, Celia Islam1, Ashley Ubaldini, Yun Ji, Luca Gattinoni, Ferri Soheilian, Xiantao Wang, Markus Hafner, Jyoti Shetty, Bao Tran, Parthav Jailwala, Maggie Cam, Martin Lang, Donna Voeller, William C. Reinhold, Vinodh Rajapakse, Yves Pommier, Roberto Weigert, W. Marston Linehan and Stanley Lipkowitz.

Macrophilones from the Marine Hydroid Macrorhynchia philippina Can Inhibit ERK Cascade Signaling
2018 July 06
Pengcheng Yan, Daniel A. Ritt, Katherine Zlotkowski, Heidi R. Bokesch, William C. Reinhold, John S. Schneekloth, Jr., Deborah K. Morrison and Kirk R. Gustafson.

CellMinerCDB for Integrative Cross-Database Genomics and Pharmacogenomics Analyses of Cancer Cell Lines
2018 Dec 21
Vinodh N. Rajapakse, Augustin Luna, Mihoko Yamade, Lisa Loman, Sudhir Varma, Margot Sunshine, Francesco Iorio, Fabricio G. Sousa, Fathi Elloumi, Mirit I. Aladjem, Anish Thomas, Chris Sander, Kurt W. Kohn, Cyril H. Benes, Mathew Garnett, William C. Reinhold and Yves Pommier.

Temozolomide in the Era of Precision Medicine.
Cancer Res. 2017 Feb 15. [Epub ahead of print].
Thomas A, Tanaka M, Trepel J, Reinhold WC, Rajapakse VN, Pommier Y.

Phosphorylated fraction of H2AX as a measurement for DNA damage in cancer cells and potential applications of a novel assay.
Plos One. 2017 Feb 3.
Ji J, Zhang Y, Redon CE, Reinhold WC, Chen AP, Fogli LK, Holbeck SL, Parchment RE, Hollingshead M, Tomaszewski JE, Dudon Q, Pommier Y, Doroshow JH, Bonner WM.

The NCI-60 Methylome and its Integration into CellMiner.
Cancer Res. 2017 Feb 1. pii: [Epub ahead of print].
Reinhold WC, Varma S, Sunshine M, Rajapakse V, Luna A, Kohn KW, Stevenson H, Wang Y, Heyn H, Nogales V, Moran S, Goldstein DJ, Doroshow JH, Meltzer PS, Esteller M, Pommier Y.

Cytidine deaminase deficiency reveals new therapeutic opportunities against cancer.
Clin Cancer Res. 2017 Apr 15. pii: clincanres.0626.2017. [Epub ahead of print].
Mameri H, Bièche I, Meseure D, Marangoni E, Buhagiar-Labarchède G, Nicolas A, Vacher S, Onclercq-Delic R, Rajapakse V, Varma S, Reinhold WC, Pommier Y, Amor-Guéret M.

DNA-Targeted Precision Medicine; Have We Been Caught Sleeping?
Trends in Cancer. 2016 Dec 27. [Epub ahead of print].
Reinhold WC, Thomas A, Pommier Y.

A replicator-specific binding protein essential for site-specific initiation of DNA replication in mammalian cells.
Nat Commun. 2016 Jun 8;7:11748. doi: 10.1038/ncomms11748.
Zhang Y, Huang L, Fu H, Smith OK, Lin CM, Utani K, Rao M, Reinhold WC, Redon CE, Ryan M, Kim R, You Y, Hanna H, Boisclair Y, Long Q, Aladjem MI.

rcellminer: exploring molecular profiles and drug response of the NCI-60 cell lines in R.
Bioinformatics. 2016 Apr 15;32(8):1272-4. doi: 10.1093/bioinformatics/btv701. Epub 2015 Dec 3.
Luna A, Rajapakse VN, Sousa FG, Gao J, Schultz N, Varma S, Reinhold W, Sander C, Pommier Y.

Epigenetic inactivation of the putative DNA/RNA helicase SLFN11 in human cancer confers resistance to platinum drugs.
Oncotarget. 2016 Jan 19;7(3):3084-97. doi: 10.18632/oncotarget.6413.
Nogales V, Reinhold WC, Varma S, Martinez-Cardus A, Moutinho C, Moran S, Heyn H, Sebio A, Barnadas A, Pommier Y, Esteller M.

Current dichotomy between traditional molecular biological and omic research in cancer biology and pharmacology.
World J Clin Oncol. 2015 Dec 10;6(6):184-8. doi: 10.5306/wjco.v6.i6.184.
Reinhold WC.

Using CellMiner 1.6 for Systems Pharmacology and Genomic Analysis of the NCI-60.
Clin Cancer Res. 2015 Jun 5. pii: clincanres.0335.2015. [Epub ahead of print].
Reinhold WC, Sunshine M, Varma S, Doroshow JH, Pommier Y.

Bisphosphonates as new anticancer agents?
Bull Cancer. 2015 Apr;102(4):297-9.
Robert J, Reinhold WC.

The 15kDa selenoprotein and thioredoxin reductase 1 promote colon cancer by different pathways.
PLoS One. 2015 Apr 17;10(4):e0124487.
Tsuji PA, Carlson BA, Yoo MH, Naranjo-Suarez S, Xu XM, He Y, Asaki E, Seifried HE, Reinhold WC, Davis CD, Gladyshev VN, Hatfield DL.

Alterations of DNA repair genes in the NCI-60 cell lines and their predictive value for anticancer drug activity.
DNA Repair. 2015 Feb 11. pii: S1568-7864(15)00023-3.
Sousa FG, Matuo R, Tang SW, Rajapakse VN, Luna A, Sander C, Varma S, Simon PH, Doroshow JH, Reinhold WC, Pommier Y.

Using drug response data to identify molecular effectors, and molecular "omic" data to identify candidate drugs in cancer.
Hum Genet. 2015 Jan;134(1):3-11. doi: 10.1007/s00439-014-1482-9. Epub 2014 Sep 12.
Reinhold WC, Varma S, Rajapakse VN, Luna A, Sousa FG, Kohn KW, Pommier YG.