EXEL-7647

Key	Value
Synonyms:	EXEL-7647 XL-647 X1042 XL647 TESEVATINIB 776762
National Service Center# (NSC#):^1,2	776762
CAS#:	781613-23-8
PubChem#:	NA
Mechanism of Action:	PK:EGFR,ERBB2,SRC,VEGFR
Status:	Clinical trial
Molecular Formula:	C24H25Cl2FN4O2
Smiles:	COc1cc2c(Nc3ccc(Cl)c(Cl)c3F)ncnc2cc1OCC4C[C@H]5CN(C)C[C@H]5C4

EXEL-7647 is in CellMinerCDB, a searchable tool integrating cancer cell line pharmacogenomics data to link gene and drug activity signatures.

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EXEL-7647 is in CellMiner (NCI-60),a database and query tool designed for the cancer research community to facilitate integration and study of molecular and pharmacological data for the NCI-60 cancerous cell lines.

Click Here to Access CellMiner (NCI-60)

If you use content from this page, CellMinerCDB or CellMiner (NCI-60), please cite: Luna A et al. 2021. PMID: 33196823, Rajapakse VN et al. 2018. PMID: 30553813, Luna et al. 2016., PMID: 26635141, and Reinhold et al. 2012., PMID: 22802077.

Available Data

Visit CellMinerCDB to interactively explore available pharmacogenomics data for EXEL-7647.

Visit CellMiner (NCI-60) to explore NCI-60 related analysis for EXEL-7647.

EXEL-7647 is available in the following datasets
NCI60	GDSC-MGH-Sanger	GDSC1 drugs	GDSC2 drugs	CCLE-Broad-MIT	CTRP-Broad-MIT	NCI-DTP SCLC	PRISM-Broad-MIT	NCI60-DTP Almanac
776762	NA	NA	NA	NA	NA	NA	XL647	NA

¹ NSC#: Originally known as Cancer Chemotherapy National Service Center number, the NSC# is an identifying number assigned by NCI-DTP to an agent or product (e.g. small molecule or biological agent).
² Most structures have a unique NSC number but over the years a small percentage of structures or agents may have been assigned more than one NSC number. In the case of salts, different salt forms (e.g. HCl, HOAc) are designated with separate NSC numbers.