AMG-51

Key	Value
Synonyms:	AMG-51 A-6043 AMG51 794646
National Service Center# (NSC#):^1,2	794646
CAS#:	890019633
PubChem Substance#:	440810118
PubChem Compound#:	11858109
Mechanism of Action:	PK:MET
Status:	Clinical trial
Molecular Formula:	C34H33F2N5O5
Smiles:	COc1cc2c(Oc3ccc(cc3F)C4=CN=C(Nc5ccc(F)cc5)N(C)C4=O)ccnc2cc1OCCCN6CCOCC6

AMG-51 is in CellMinerCDB, a searchable tool integrating cancer cell line pharmacogenomics data to link gene and drug activity signatures.

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AMG-51 is in CellMiner (NCI-60),a database and query tool designed for the cancer research community to facilitate integration and study of molecular and pharmacological data for the NCI-60 cancerous cell lines.

Click Here to Access CellMiner (NCI-60)

If you use content from this page, CellMinerCDB or CellMiner (NCI-60), please cite: Luna A et al. 2021. PMID: 33196823, Rajapakse VN et al. 2018. PMID: 30553813, Luna et al. 2016., PMID: 26635141, and Reinhold et al. 2012., PMID: 22802077.

Available Data

Visit CellMinerCDB to interactively explore available pharmacogenomics data for AMG-51.

Visit CellMiner (NCI-60) to explore NCI-60 related analysis for AMG-51.

AMG-51 is available in the following datasets
NCI60	HTS384 NCI60	GDSC-MGH-Sanger	GDSC1 drugs	GDSC2 drugs	CCLE-Broad-MIT	CTRP-Broad-MIT	NCI-DTP SCLC	PRISM-Broad-MIT	NCI60-DTP Almanac	NCATS IC50	NCATS AUC
794646	794646	NA	NA	NA	NA	NA	NA	NA	NA	amg-51	amg-51

¹ NSC#: Originally known as Cancer Chemotherapy National Service Center number, the NSC# is an identifying number assigned by NCI-DTP to an agent or product (e.g. small molecule or biological agent).
² Most structures have a unique NSC number but over the years a small percentage of structures or agents may have been assigned more than one NSC number. In the case of salts, different salt forms (e.g. HCl, HOAc) are designated with separate NSC numbers.