is generated by the Genomic and Pharmacology Facilit, DTB, CCR, NCI, NIH. It is a database and query tool designed for the cancer research community to facilitate integration and study of molecular and pharmacological data for the NCI-60 cancerous cell lines. The NCI-60, a panel of 60 diverse human cancer cell lines used by the Developmental Therapeutics Program of the U.S. National Cancer Institute to screen over 100,000 chemical compounds and natural products (since 1990).

To cite the tool, the primary literature references are (Shankavaram, BMC Genomic, 2009 and Reinhold, Cancer Res, 2012).

Press articles reviewing CellMiner may be accessed here (Cancer Discovery) (CCR Connections) (NCI press release) (FierceBiotechIT).

Press articles reviewing the Exome data set may be accessed here (Time Magazine) (NPR) (Forbes) (Los Angeles Times) (U.S. News Health) (GenomeWeb Daily News).

Subsequent builds will include additional molecular data sets and integrative capabilities.

Release Notes

Version 2020.4 - 12/22/2020
  • Gene version: Hg19 from NCBI
  • DTP drug pull date: 12/01/2020
  • Database version: v2.5
  • Added drug almanac combo scores in the cell line signature analysis
  • Added querying drug almanac data with NSC pairs or compound name pairs
  • Added download drug almanac data in the download data set page
  • Updated phenotypic parameters in Pattern Comparison
Historical Release Notes

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CellMiner Development Team

Jeffrey Yang-Hsin Wang, Sudhir Varma, William Reinhold and Yves Pommier prior contributors