CellMiner™

CellMiner is a database and query tool designed for the cancer research community to facilitate integration and study of molecular and pharmacological data for the NCI-60 cancerous cell lines. The NCI-60, a panel of 60 diverse human cancer cell lines used by the Developmental Therapeutics Program of the U.S. National Cancer Institute to screen over 100,000 chemical compounds and natural products (since 1990).

• To cite the tool, the primary literature references are
  • Shankavaram, BMC Genomic, 2009
  • Reinhold, Cancer Res, 2012
• Press articles reviewing CellMiner may be accessed here
  • CCR Connections
  • CCR News
  • Cancer Discovery
  • Fierce Biotech MedTech
• Press articles reviewing the Exome data set may be accessed here
  • Time Magazine [PDF, 0.16 MB]
  • NPR [PDF, 0.50 MB]
  • Forbes [PDF, 0.26 MB]
  • Los Angeles Times [PDF, 1.64 MB]
  • U.S. News Health [PDF, 0.07 MB]
  • GenomeWeb Daily News [PDF, 0.08 MB]

How to find the information you need in CellMiner side navigation

• NCI-60 Analysis Tools link to access automation of several commonly done analyses (Reinhold, Cancer Res, 2012).
• Query Genomic Data link to query the normalized data sets for information. You can search the data using single identifiers, or a list of identifiers, customize your data annotation, and select your output data format.
• Query Drug Data link to query the drug data for information. You can search the data using single identifiers, or a list of identifiers, customize your data annotation, and select your output data format.
• Download Data Sets link to download the entire data set, in either raw or normalized versions.
• Cell Line Metadata link to view metadata on the NCI-60 panel. Included are tissue type, patient demographics, prior treatment, histology, source, ploidy, p53 status, DNA fingerprint data, etc.
• Data Set Metadata link to get background information about each data set.
• Release Notes link to get information about the current version of CellMiner and history release.

Other Useful Pages

• FDA Approved Drug List The FDA approved drug list in the latest CellMiner database.
• Clinical Trial Drug List The Clinical Trail drug list in the latest CellMiner database.

Resources

• For other bioinformatic tools and database resources from GPF go to the Genomics and Pharmacology Facility website.
• For additional drug, dataset and molecular target data see the NCI Developmental Therapeutics Program website.

CellMiner Development Team

Jeffrey Yanghsin Wang, Sudhir Varma, William Reinhold and Yves Pommier