Release Notes

Version 2024.1 - 03/27/2024
  • Gene version: Hg19 from NCBI
  • DTP drug pull date: 03/01/2024
  • Database version: v2.12
  • FDA NSCs passed QC: 318
  • Clinical trial NSCs passed QC: 563
  • Added NCI-60 Cell Surface Protein data
Version 2023.3 - 09/24/2023
  • Gene version: Hg19 from NCBI
  • DTP drug pull date: 09/01/2023
  • Database version: v2.11
  • FDA NSCs passed QC: 316
  • Clinical trial NSCs passed QC: 551
Version 2023.1 - 03/26/2023
  • Gene version: Hg19 from NCBI
  • DTP drug pull date: 03/02/2023
  • Database version: v2.10
  • Implemented new download data set page
Version 2022.3 - 09/30/2022
  • Gene version: Hg19 from NCBI
  • DTP drug pull date: 09/01/2022
  • Database version: v2.9
  • Implemented US Web Design System UI/UX
  • Updated drug status list
  • Added Histone Protein H3K27ac and H3K4me3
Version 2022.1 - 04/03/2022
  • Gene version: Hg19 from NCBI
  • DTP drug pull date: 03/01/2022
  • Database version: v2.8.1
  • Refactored code for drug z-score database batch scripts.
Version 2021.2 - 08/29/2021
  • Gene version: Hg19 from NCBI
  • DTP drug pull date: 08/01/2021
  • Database version: v2.7
  • Updated to limit the Pattern Comparison Analysis request job to one at a time.
Version 2021.1 - 04/22/2021
  • Gene version: Hg19 from NCBI
  • DTP drug pull date: 04/01/2021
  • Database version: v2.6
  • Added user input validation in the query drug almanac data
  • Added a new page to display drug status list for FDA approved and Clinical trial drugs
Version 2020.4 - 12/22/2020
  • Gene version: Hg19 from NCBI
  • DTP drug pull date: 12/01/2020
  • Database version: v2.5
  • Added drug almanac combo scores in the cell line signature analysis
  • Added querying drug almanac data with NSC pairs or compound name pairs
  • Added download drug almanac data in the download data set page
  • Updated phenotypic parameters in Pattern Comparison
Version 2020.3 - 07/15/2020
  • Gene version: Hg19 from NCBI
  • DTP drug pull date: 10/23/2019
  • Database version: v2.4.2
  • Changed cell line signature and cross-correlation analysis entry limit to 10
  • Added release notes in home page and created a historical release notes page
  • Added NCI-60 Almanac combo score data in the database
version 2020.2 - 05/16/2020
  • Gene version: Hg19 from NCBI
  • DTP drug pull date: 2017
  • Database version: v2.2
  • Newly added dataset: RNA:RNA-seq, Protein: SWATH
  • Newly updated analysis:
    • RNA-seq in cell line signature, pattern comparison and drug vs gene variant/isoforms
    • Protein SWATH in cell line signature, cross-correlations and pattern comparison
version 2020.1 - 04/06/2020
  • Gene version: Hg19 from NCBI
  • DTP drug pull date: 2017
  • Database version: v2.2
  • Renamed Protein: Lysate Array to Protein: Antibody Array DTB
  • Renamed Protein: Antibody Array to Protein: Antibody Array MDA
  • Updated Protein: Antibody Array MDA in Data Set Metadata page
Cellminer Data Synopsis
Database Version 2.8.1 2.9 2.10 2.11 2.12
Starting Date 04/2022 09/2022 03/2023 09/2023 03/2024
Drugs
Total compounds 1 56,461 56,920 57,287 57,455 57,673
Compounds (passed QC) 2 24,360 24,620 24,853 24,980 25,147
Known MOA 3 1,427 1,460 1,460 1,460 1,460
FDA NSCs 4 286 438 438 438 438
FDA NSCs passed QC 5 218 314 314 316 318
FDA drugs 6 201 325 325 325 325
FDA drugs passed QC 7 155 232 232 233 234
Clinical trial NSCs 8 772 739 739 739 739
Clinical trial NSCs passed QC 9 574 546 546 551 563
Clinical trial drugs 10 721 691 691 691 691
Clinical trial drugs passed QC 11 542 516 516 520 530
DNA
aCGH (DNA copy number) 12 23,222 23,222 23,222 23,222 23,222
AA changing gen. var. 13 12,945 12,945 12,945 12,945 12,945
Function affecting gen. var. 14 9,307 9,307 9,307 9,307 9,307
DNA methylation 15 17,552 17,552 17,552 17,552 17,552
RNA
microRNAs 16 360 360 360 360 360
Microarray Transcript z scores total 17 26,186 26,186 26,186 26,186 26,186
RNA-seq gene transcripts 18 23,808 23,808 23,808 23,808 23,808
Protein
Proteins, RPLA (162 antibodies) 19 94 94 94 94 94
Proteins, mass spectrometry 20 3,162 3,162 3,162 3,162 3,162
Phenotype
Phenotypic parameters 21 73 73 73 73 73
Totals
Molecular totals 22 107,329 107,329 107,329 107,329 107,329
Compound activity totals 23 24,360 24,620 24,853 24,980 25,147
  1. The DTP compounds and drugs loaded onto Cellminer.
  2. The compounds that passed Cellminer quality control as described in (PMID 22802077).
  3. The number of compounds have known drug mechanism of action (MOA).
  4. The number of National Service Center (NSC) identifiers for Food and Drug Administration (FDA) approved drugs. There may be more than one per drug.
  5. The number of National Service Center (NSC) identifiers for Food and Drug Administration (FDA) approved drugs that passed CellMiner QC. There may be more than one per drug.
  6. The number of drugs approved by the Food and Drug Administration (FDA).
  7. The number of drugs approved by the Food and Drug Administration (FDA) and passed CellMiner QC.
  8. The number of National Service Center (NSC) identifiers for clinical trial drugs. There may be more than one per drug.
  9. The number of National Service Center (NSC) identifiers for clinical trial drugs that passed CellMiner QC. There may be more than one per drug.
  10. The number of drugs in, or have been in, some level of clinical trial.
  11. The number of drugs in, or have been in, some level of clinical trial and passed CellMiner QC.
  12. The number of unique genes with DNA copy number from array comparative hybridization (aCGH) (PMID 24670534).
  13. The number of unique genes with DNA exome sequence amino acid (AA) changing genetic variants (PMID 26048278).
  14. The number of unique genes with DNA exome sequence protein function affecting genetic variants (PMID 26048278).
  15. The number of unique genes with DNA methylation levels (PMID 27923837).
  16. The number of unique microRNAs with transcript expression levels (PMID 20442302).
  17. The number of unique genes with transcript expression levels from microarray analysis (PMID 22802077).
  18. The number of unique genes with transcript expression levels from RNA sequencing (RNAseq) (PMID 31113817).
  19. The number of unique genes with protein expression as measured by reverse phase lysate arrays (RPLA) (PMID 14623978).
  20. The number of unique genes with protein expression as measured by mass spectrometry (PMID 31733513).
  21. The number of phenotypic parameters Pattern Comparison (PMID 26048278).
  22. The summation of aCGH DNA copy number, AA Changing gen. var., DNA methylation, microRNAs, Microarray Transcript z scores total, RNA-seq, Protein RPLA and Protein mass spectrometry.
  23. Compound activity totals are from Compounds (passed QC).